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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. GMP Manufacturing and IND Enabling Studies of Extended-Release PNA5: ANovel Therapeutic for Treating Cognitive Impairment in Patients at-risk for Alzheimer's Disease-Related Dementias and Vascular

    SBC: Proneurogen, Inc            Topic: NIA

    Vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer’s disease related dementias (ADRD) significantly contribute to the 47 million people world-wide who suffer with dementia. This number is estimated to increase to over 130 million people by 2050. Several studies have shown that VCID and conversion to ADRD are strongly correlated with vascular disease, inflammation an ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Neurosessments: Developing a quick, objective motor test to prompt cognitivetesting in primary care

    SBC: NEUROSESSMENTS LLC            Topic: NIA

    PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is the leading cause of dementia in the United States, affecting one out of every nine older adults. However, Alzheimer’s disease and related dementias (AD/ADRD) can be difficult to diagnose, with physicians missing nearly half of all probable dementia cases. Rates of missed diagnosis are even higher among Black older adults. The majority of ph ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Computational Development of Novel Dyslipidemia Therapeutic Candidates to Disrupt ApoC-III Conformation

    SBC: IMETABOLIC BIOPHARMA CORP            Topic: NHLBI

    Project Abstract Cardiovascular Disease (CVD) is a significant threat in the United States and developing countries across the globe. Widely associated with elevated low density lipoprotein cholesterol (LDL-c), therapeutic interventions are primarily focused on reduction of LDL-c plasma levels. Despite the ability to therapeutically reach these target levels, many patients maintain high cardiovasc ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. A Point-of-Care Test for Rapid Diagnosis of Valley Fever

    SBC: CACTUS BIO LLC            Topic: NIAID

    A Point-Of-Care Test for Rapid Diagnosis of Valley Fever PROJECT SUMMARY Coccidioidomycosis (Valley Fever) is a respiratory disease caused by inhalation of spores from the desert soil- dwelling fungus, Coccidioides spp. In endemic areas, up to 30% of community acquired pneumonia (CAP) is caused by Coccidioides spp.1 Valley Fever mimics other viral and bacterial respiratory infections and is challe ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Development of serologic test for early risk stratification of islet autoimmunity in genetically predisposed T1D individuals

    SBC: BIOMORPH TECHNOLOGIES LLC            Topic: NIAID

    PROJECT SUMMARY/ABSTRACT Type 1 diabetes (T1D) is a serious multi-factorial chronic autoimmune disease with an annual 3% increase in the incidence rate that constitutes a major public health challenge and financial burden. T1D involves genetic predisposition, immune system response, and environmental factors that lead to disease initiation and progression. Due to the lack of curative therapies for ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Islet dosing and loading density in injection molded macroencapsulation devices

    SBC: IMMUNOSHIELD THERAPEUTICS INC.            Topic: 200

    PROJECT SUMMARY/ABSTRACT: Clinical islet transplantation is a promising alternative therapy for the treatment of type 1 diabetes, with the potential to reduce or eliminate secondary complications and adverse events. The potent immune response to islets remains the greatest challenge to long-term engraftment and function, which necessitates large numbers of islets and typically multiple pancreatic ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Accelerated absorption of insulin via a subcutaneously implanted, vascularized micro-chamber

    SBC: PROCYON TECHNOLOGIES LLC            Topic: 200

    Project Summary In Type I diabetic (T1D) patients, insulin is injected into the subcutaneous (SC) tissue, by needle or a pump and SC cannula. A bolus of insulin SC reaches its peak in about one hour or more. This slow absorption is in dramatic contrast to the secretion of insulin into the blood by the normal human pancreas, a process measured in seconds. Consequently, patients with T1D often strug ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Developing a new aspiration catheter solution for the treatment of large and medium vessel occlusions

    SBC: ANEUVAS TECHNOLOGIES INC            Topic: 104

    Project Summary/Abstract Stroke is the leading cause of serious long-term disability and accounts for 4.6 million disabled people in the United States. Stroke-related costs total over $46 billion in the United States each year.1 Of the nearly 800,000 Americans who have a stroke per year, 87% experience ischemic stroke1, of which 49%-86% are attributed to either large vessel occlusions (LVO) or med ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Biomarkers for Brain Resetting as an Assistive Tool in the Treatment of Status Epilepticus

    SBC: Epifocus LLC            Topic: 104

    The proposed phase-I STTR research is an interdisciplinary effort to develop more effective clinical management of Status Epilepticus (SE) in collaboration with one of the leading neurological institutes in the world, the Barrow Neurological Institute in Phoenix, Arizona. SE is a life-threatening neurological emergency that can occur without warning and is characterized by recurrent seizures witho ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Home Monitoring of Metabolic Disorders

    SBC: SEQUITUR HEALTH CORP            Topic: NICHD

    PROJECT SUMMARY This proposal is submitted in direct response to NOT-HD-22-009 Notice of Special Interest (NOSI): Innovative Technologies to Improve Assessments, Interventions, and Outcomes for Individuals with Intellectual and Developmental Disabilities [IDD] (R43/R44). Persons of all ages with certain metabolic disorders are at-risk for metabolic crises when a certain metabolite accumulates, whi ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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