Award Data

The broader impact of this Small Business Innovation Research (SBIR) Phase I project is to reimagine bio-manufacturing with a novel platform technology that could boost the yields of many products, including food additives, biomaterials precursors, biofuels, and pharmaceuticals. The technological advancement addresses a fundamental issue that limits conventional bio-fermentation, which is that pro ...

1. Problem StatementCurrent industrial-scale rare earth element separation technologies are based on solvent extraction schemes which produce large amounts of undesirable chemical waste, including the loss of volatile organic solvents and reagents employed in the treatment of feed streams. These concerns have severely limited the development of U.S.-based rare earth element separation facilities. ...

High-quality, defect free, and consistent thickness Proton Exchange Membrane (PEM) films are required to ensure maximum efficiency and longevity over the life of hydrogen fuel cells or electrolyzers utilizing this technology. The current technologies of PEM film Quality Assurance (QA) and defect detection rely on human inspection, which can be subjective and labor intensive, or measurement technol ...

The broader impact of this Small Business Technology Transfer (STTR) Phase II project involves continued development of technology to extend the therapeutic window of cell-based tissue regeneration therapies. This technology could significantly enhance the scientific understanding of cellular therapies and enable the healing of injuries more rapidly and less invasively than current techniques. A s ...

Project SummaryAccumulated snowpack is a major source of water throughout the United States. Accuratelymonitoring snow on the northern plains is a significant need for streamflow forecasting andreservoir management. This has been demonstrated by the US Army Corp of Engineersestablishment of the Upper Missouri River Basin Plains Snow and Soil Moisture MonitoringNetwork. The availability of a low-co ...

This project will demonstrate the utilization of wood biomass feedstock to produce grapheneproducts through a less expensive more environmentally friendly process. The wood feedstock isfirst pyrolyzed to biochar then the process developed at the University of Wyoming converts thebiochar to graphene oxide a viable product. Further treatment produces reduced graphene oxideand graphene nanosheets als ...

Project Summary The goal of this Fast Track STTR project is to determine proof-of-principle and efficacy of a novel blood brain barrier (BBB) penetrating therapeutic nanoparticle for the potential treatment of otherwise intractable brain tumors like glioblastoma multiforme (GBM). This project seeks to demonstrate that novel, targetable nanoparticles can delivery therapeutic substances to human bra ...

The goal of this project is to develop a treatment booth with technology that allows opioid treatment programs to remotely dispense, either methadone or buprenorphine, under medical observation through telemedicine to a patient in a treatment booth. We believe that robotic automation is the ideal application to perform the same mechanical functions of the nurse at the dosing window. Specifically, ...

Abstract Pharmacogenomics, the study of how an individual's genetic makeup affects their response to drugs, has undergone rapid advancements. This has occurred alongside a decrease in the cost of genotyping technology, making implementation of pharmacogenomics into clinical practice increasingly feasible. Personalized medicine leveraging pharmacogenomics is gaining momentum to optimize drug choice ...

Project Summary / Abstract DermaXon's project goal is to develop efficacious, substrate-based, selective inhibitors of CYP26s, the enzymes responsible for the metabolism of all-trans retinoic acid (atRA) in the epidermis, as an oral treatment for severe recalcitrant acne. This approach will provide an improved acne therapeutic without the adverse effects associated with currently marketed retinoid ...