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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Multiphysics Motor Design Software Package Using MFEM

    SBC: IERUS TECHNOLOGIES INC            Topic: C5501b

    C55-01b-270447-AbstractAs device designs become more complex and incorporate new, advanced technologies and materials, accurate simulations of multi-physics phenomenology become critical to ensuring that such design and analysis efforts are successful. The diversity of problems of interest to the Department of Energy (DOE) and wider audiences includes examples such as electric motor/generator desi ...

    SBIR Phase I 2023 Department of Energy
  2. Advanced Machine Learning for Explosives Detection

    SBC: STREAMLINE AUTOMATION LLC            Topic: DHS231004

    Transportation Safety Officers (TSOs) currently use a multi-step decision tree to screen and resolve an alarm of a suspicious object in crowded and high-throughput environments, such as aviation and security checkpoints. In high-throughput environments, this can lead to information overload and mental fatigue. Homeland Security desires a more capable integrated Alarm Resolution (AR) sensor suite, ...

    SBIR Phase I 2023 Department of Homeland Security
  3. ACIS: A Machine Learning Platform for Chemical Signature and Toxicity Prediction

    SBC: CFD RESEARCH CORPORATION            Topic: DHS231007

    The rapid detection of highly toxic compounds, such as chemical warfare agents, toxic industrial compounds, pharmaceutical-based agents, and non-traditional agents, is paramount to industrial and national security. While multiple chemical detection platforms exist, the ability to detect toxic compounds is fundamentally limited by the available reference database of known chemical signatures. Recen ...

    SBIR Phase I 2023 Department of Homeland SecurityCountering Weapons of Mass Destruction
  4. SBIR Phase I:Predictive ex vivo solid tumor biopsy-chip multiplexer for screening anticancer agents

    SBC: CerFlux, Inc.            Topic: BM

    The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project lies in enhancing health outcomes and quality of life for cancer patients. Each year, over 1.7 million Americans are diagnosed with cancer, and treatment turns out to be ineffective for approximately 75% of those receiving systemic therapy. This failure is because every tumor is distinct in ma ...

    SBIR Phase I 2023 National Science Foundation
  5. ThreatHelm: Enhanced Cyber Resiliency

    SBC: SENTAR, INC.            Topic: C5640h

    With the expectation of global nuclear energy to continue growth for the next several decades, the threat of cyber attacks will follow due to the increasing importance of the energy sector, emerging technologies and the continuously evolving capabilities of potential adversaries. Current accepted approaches for managing cyber risks focus on preventing access to critical systems by using tools such ...

    SBIR Phase I 2023 Department of Energy
  6. Production of largemouth bass for the food fish market using commercial split-pond systems

    SBC: AMERICAN SPORT FISH HATCHERY MANAGEMENT GROUP LLC            Topic: 87

    Largemouth bass (LMB - Micropterus salmoides) production for the foodfish market is growing inthe US.Traditionally LMB producers in the US have relied on traditional earthen ponds as theirprimary production system for culturing this species. Yearly LMB producers in the SoutheasternUS using traditional earthen ponds as the primary production unit are plagued by low survival slowgrowth poor food con ...

    SBIR Phase I 2023 Department of Agriculture
  7. Harmony AI: State of the Art Natural Language Processing for Genetic Engineering

    SBC: CFD RESEARCH CORPORATION            Topic: 400

    Project Summary/Abstract: Computational techniques for gene engineering, such as codon optimization, use synonymous codon changes to increase protein production. Applications for these computational gene optimizations include recombinant protein drugs, nucleic acid therapies, and mRNA vaccines. Although codon optimization increases protein production in certain systems, synonymous changes to a gen ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Harmony AI: Natural Language Processing Enabling Advanced Biomanufacturing

    SBC: CFD RESEARCH CORPORATION            Topic: 400

    Project Summary/Abstract: Recombinant proteins have a wide range of applications, from pharmaceutical products, drug discovery, protein-based polymers for drug delivery, antibodies enzymes, and sustainable technologies such as textiles and vegan food production such as the impossible burger. Towards meeting these increased demands by replacing batch culture with continuous culture reduces overhead ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Bionanomatrix coating to enhance antibacterial effects while reducing inflammation of knee joint implants

    SBC: ENDOMIMETICS LLC            Topic: NIAMS

    Osteoarthritis (OA) is a degenerative joint disease that affects over 32 million individuals in the United States, causing debilitating joint destruction and chronic joint pain, stiffness, and physical impairment. To restore and improve the patient’s quality of life, total knee arthroplasty (TKA) is the most common surgical intervention performed for OA to replace the compromised joint with arti ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. An Inhaled Microbiome-Targeted Biotherapeutic for Treatment of COPD

    SBC: ALVEOLUS BIO, INC.            Topic: NHLBI

    PROJECT SUMMARY - ResBiotic Inc. is developing its lead drug product, RB1000, a spray-dried powder com- prised of an inhaled biotherapeutic API for treatment of neutrophilic inflammation and disease progression in COPD patients. COPD is a chronic degenerative disease that is the fourth leading cause of death in the U.S., where it predominantly results from tobacco smoke exposure. Acute exacerbatio ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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