Award Data

THE SMALL FAMILY FARM IN WEST CENTRAL MISSOURI ECONOMICALLY DEPRESSED. NUMEROUS STUDIES HAVE BEEN MADE ON THE DECLINE OFFAMILY FARM, THE AGING POPULATION, AND MIGRATION FROM THE FAMILY FARM. WHEN A FARM FAMILY LEAVES THE FARM, MANY PEO- PLE FROM THE SMALL TOWN ARE WITHOUT A SOCIAL FUNCTION SO THEY TOO MIGRATE. THE PURPOSE OF THIS PROJECT IS TO RESEARCHWITH FARM FAMILIES ALTERNATIVES TO THIS MIGRAT ...

THE AIM OF THIS REVISED PROPOSAL IS TO DEVELOP LEVEL IV INTERACTIVE VIDEODISC COURSEWARE TO ENABLE PERINATAL NURSES TO ATTAIN/MAINTAIN ELECTRONIC FETAL HEART MONITORING (EFHM) SKILLS SIGNIFICANT TO EARLY DETECTION/INTERVENTION IN FETAL DISTRESS. COURSEWARE WILL BE DESIGNED WITH FLEXIBILITY TO ENSURE RELEVANCE FOR PERINATAL NURSE PRACTITIONERS' CONTINUING EDUCATION NEEDS AND FOR NURSES IN BASIC/GRA ...

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A MICROMECHANICAL ANALYTICAL MODEL WILL BE DEVELOPED FOR PREDICTING THE FAILURE MODES IN A FIBER REINFORCED UNIDIRECTIONAL CERAMIC MATRIX COMPOSITE. THE PROPOSED MODELWILL BE BASED ON MODIFIED SHEAR-LAG THEORY THAT WOULD ACCOUNT FOR THE RELATIVELY LARGE MATRIX STIFFNESS, UP TO FIFTY PERCENT OF THE FIBER STIFFNESS. A COMBINATION OF STRESS INTENSITY FACTOR AND MICROMECHANICS APPROACHES WILL BE EMPLO ...

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THE GOAL OF THIS PROJECT IS TO DEVELOP A MONOCLONAL ANTIBODY-BASED IMAGING REAGENT CAPABLE VISUALIZING HUMAN PARATHYROIDGLANDS. THE STUDY WILL BE DIRECTED AT ISOLATION AND CHARACTERIZATION OF HUMAN PARATHYROID-SPECIFIC MOUSE MONOCLONAL ANTIBODIES AND PRELIMINARY ANALYSIS OF THEIR TARGET ANTIGENS. AS THE CLASS AND SUBCLASS OF ANTIBODIES WILL LIKELY INFLUENCE IMAGING PROPERTIES, VARIANTS OF HYBRIDOM ...

HIGH BLOOD LEVELS OF LDL HAVE BEEN ESTABLISHED AS CAUSATIVE FOR ATHEROSCLEROSIS AND CORONARY HEART DISEASE. FOR SELECTED PATIENTS, EXTRACORPOREAL LDL REMOVAL IS THE MOST EFFECTIVE THERAPY. THE GOAL OF THIS PROJECT IS TO DEVELOP AMONOCLONAL ANTIBODY-BASED IMMUNOADSORPTION DEVICE CAPABLE OF REMOVING LOW-DENSITY LIPOPROTEIN (LDL) FROM HYPERCHOLESTEROLEMIC WHOLE BLOOD CIRCULATED IN A LOW-PRESSURE EXTR ...

STUDIES OF THE REGULATION OF CELL GROWTH AND OF ONCOGENIC TRANSFORMATION HAVE REVEALED KEY ROLES FOR VIRAL TRANSFORMING GENES AS WELL AS FOR EXTERNAL GROWTH AND DIFFERENTIATION FACTORS. CERTAIN VIRAL GENES HAVE BEEN USED IN THE TRANSFORMATION OF PRIMARY CELLS TO IMMORTALITY IN CULTURE, AND MANIPULATION OF CULTURE CONDITIONS HAS ALSO YIELDED CHANGES IN THE LIFESPAN OF SOME CELL TYPES. A PRINCIPAL G ...

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THE CENTRAL PURPOSE OF THIS RESEARCH IS TO DEVELOP A FLEXIBLE SYSTEM FOR SELECTIVE DELIVERY OF FLUORESCENT DYES, PHOTOACTIVE AGENTS, AND DRUGS TO SUBPOPULATIONS OF NEURONS DEEP WITHIN THE RODENT NERVOUS SYSTEM IN VIVO. A NOVEL LATEX NANOSPHERE DELIVERY SYSTEM (LNDS) WILL BE DEVELOPED AND REFINED TO ALLOW NEUROANATOMICAL, DEVELOPMENTAL, AND PHARMACOLOGIC STUDIES. DURING PHASE I, THE LNDS WILL BE DE ...