Award Data

DESCRIPTION (provided by applicant): IV amiodarone is the first line therapy for life threatening ventricular as well as supraventricular arrhythmias. However, the Tween 80 and benzyl alcohol diluents limits the rate of administration severely, due to hypotension and myocardial contractile depression. These adverse toxicities contribute to the high mortality of cardiac arrest patients who have ma ...

This Small Business Innovation Research (SBIR) Phase I project will develop boron-doped ultrananocrystalline diamond (UNCD) electrodes for electrochemical treatment/destruction of recalcitrant organics in industrial wastewater via direct anodic oxidation. Boron-doped diamond (BDD) film electrodes have generated considerable interest due to their ability to readily mineralize complex waste streams. ...

This Small Business Innovation Research Phase I project will investigate UNCDýý, a nanocrystalline from of smooth, thin diamond, as an anti-thrombotic coating for implantable medical devices. One of the largest problem with implantable circulatory assist devices such as artificial hearts and vascular assist devices (VADs) is the need to treat patients with anticoagulants to avoid blood clots wit ...

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer Phase I project will develop ultrananocrystalline diamond (UNCD?) as a high frequency structural layer for piezoelectrically-transduced micromachined RF resonators for MHz-GHz applications in wireless telecommunication systems. Diamond, in theory, is the ideal ...

This Small Business Innovation Research (SBIR) Phase I project will develop a cell and blood compatible, non-clotting drug-eluting prosthetic artery that can release, in a controlled manner, drugs or other small compounds that can inhibit scarring and clotting. Potential drug candidates will be loaded using various concentrations and conditions, in order to determine the release rate and dosing th ...

DESCRIPTION (provided by applicant): In the United States, it is estimated that 8 million people suffer from peripheral artery disease (PAD). PAD is characterized by a gradual reduction in blood flow to the muscular arteries of the lower extremities caused by atherosclerosis. For those with severe PAD, lower extremity bypass grafting remains the predominant option for limb salvage. Although native ...

This Phase I program proposes to synthesize novel nanoengineered ultra low out gassing elastomers and formulate high temperature capable flexible thermal control coatings as well as adhesives based on the proposed chemistries that are stable in various space environments. We have envisioned nano-engineered clusters and the innovative synthesis of the poly carborane-polysiloxanes, to surpass the pe ...

Ceramic Matrix Composites (CMCs) are emerging as mission-critical materials for a broad range of defense applications and among them, their utility for next-generation aero-turbine components are currently being pursued. SiC-based CMCs are leading candidates for this application due to their high strength, low density, and superior toughness at elevated temperatures. In this Phase I project, a new ...

High cost and poor environmental performance of CMCs are limiting their deployment in many defense applications. In particular, the JSF platform requires improved durability for a targeted CMC system which is already qualified and in production. Primary motivation for this Phase I effort is to reduce cost. CMCs, although known for their benefits of lightweight and better performance at elevated te ...

Pursuits of highly efficient and reliable solar cells place high demands on the materials and processes used in their fabrication. For extraterrestrial cells, specific efficiency is of utmost importance, and thus the ability to reduce module weight without impacting efficiency is highly desirable. Flexible solar cells are a new direction in solar cell technology and robust substrates are required. ...