Award Data

This project will explore how surgical simulation development technology may be applied to K-12 STEM education. We will develop a digital dissection based on a complete simulation of an animal specimen complete with an immersive environment, haptic feel, and accurate tissue properties. The proposed system will have the advantage of being reusable, not incurring recurring costs, being aseptic, safe ...

This SBIR Phase II project represents a new approach to transparently capture and report game-based learning (GBL) outcomes that will lead to an improved understanding of the benefits of GBL as an education technology for learning science. The K-12 educational market requires a consistent reporting system for learning outcomes in GBL products while sufficiently protecting student data. Given the i ...

This SBIR Phase II project addresses low student engagement through a dynamic video delivery environment, with a novel, real-time algorithm that adjusts the instructional pathway to each student's readiness level. Researchers consider disengaged pupils as the largest challenge facing teachers, as between 25% and 66% of students are considered to be disengaged (Taylor and Parsons 2011). As a soluti ...

Extravehicular Mobility Units (EVU) are the necessary to perform elaborate, dynamic tasks in the biologically harsh conditions of space and they have stringent requirements on physical and chemical nature of the equipment/components/processes, to ensure safety and health of the individual require proper functioning of its life-support systems. Monitoring the Portable Life Support System (PLSS) of ...

This proposal details the development of UroSeqS as a genetic cytology test to extend the utility of routinely collected urine specimens to the detection of recurrent bladder cancer UroSeqS is a genetic cytology assay that achieves sensitivity and specificity through identifying DNA mutations causative of cancer from routinely collected clinical specimens An innovative approach is used toanalyz ...

The broader impact/commercial potential of this project is the result of introducing a new generation of low-power wireless sensors for detecting Acoustic Emission events and detecting fatigue damage in structures. According to the Federal Highway Administration (FHWA), the US transportation infrastructure has 605,102 operational bridges, of which 66,561 are structurally deficient. In particular, ...

Abstract Antibacterial resistance is a global public health crisis Antibiotic resistant Clostridium difficile is responsible for more than deaths in US each year and the infection represents an urgent threat to public health worldwide Of most concern is that the incidence of C difficile infection CDI and disease severity is rapidly increasing in recent years due to the emergence of hy ...

Project Summary Production of HIV envelope protein Env trimeric gp cleaved to gp gp for clinical studies is a critical objective for vaccine development Its conformational plasticity which allows it to adopt multiple conformational states important for function often makes its expression and purification very difficult Our recent work shows a route for overcoming this probl ...

In the era of growing antibiotic resistancelife threatening infections with several bacterial pathogens are cause for major concernApproved vaccines exist only for a handful of bacterial pathogensEven when a vaccine is available invasive bacterial diseases can occur due to lack of serotype coveragepoor vaccine response among vaccinated populationsor because many simply don t get vaccinatedThusinno ...

Radiopharmaceutical therapyRPTis an emerging cancer treatment that delivers radiation directly to cancer cellsThe recent FDA approval ofRa Xofigotmfor resistant metastatic prostate cancer and its commercial success provides an example of the therapeutic and commercial potential of this modalityIn additiondrug companies have large libraries of targets and targeting moleculesProgress in chelators an ...