Award Data

We propose to develop a nanofluidics-based biosensor system for detection and quantitation of biological threat agents. The proposed system will harness the potential of recently discovered nanofluidic phenomena, not possible in microfluidic/capillary systems, to enhance rapid and sensitive sample preparation and detection. Specifically, we will develop a nanofluidics-based device to separate and ...

Increases in amount and diversity of high-throughput data presents tremendous organizational and analysis challenges to researchers. Our objective in this effort is to address these challenges by designing and implementing a database management system (cipherDB) for the storage, management, analysis, and visualization of diverse biological data types. The Phase I design and implementation of ciphe ...

In Phase II, we propose to develop high saturation current photodiodes that will meet the following design criteria: (a) Responsivity > 0.65 A/W, (b) 1 dB compression current > 100 mA, (c) Bandwidth DC to 18 GHz,(d) Wavelength response of 1300 to 1550 nm, and (e) OIP3 of +50 dBm. Three different photodiode designs will be tested for maximum saturation current: Partially Depleted Absorber (PDA), D ...

The technical problem: In the event of a terrorist attack with a “dirty bomb”, there would be an urgent need to distinguish between those who have and have not been exposed to radiation, in order to perform rapid triage. First responders and emergency health workers would require a biological dosimetric test for radiation exposure that is rapid, accurate, and non-invasive. The opportunity: a m ...

In prior and ongoing, unrelated work in electrochromics, this firm developed unique, thin, flexible, double-sided, metallized (Au, Pt), microporous membranes, incorporating Conducting Polymer (CPs). Expected to have very high electro-osmotic flow capacities, they are useful for active water vapor transport through CBD-protective membranes for military uses such as hardened military facilities, s ...

Based on the success of our Phase I feasibility research, we propose to continue the project for the automated objective speech intelligibility assessment system. It consists of a pair of head and torso simulators placed at the same distance as typical face-to-face communication, a power amplifier, a laptop computer, a speech recognizer, and console software. The simulator has acoustic properties ...

Scientists have made a lot of efforts to achieve subwavelength imaging or super-resolution imaging with a slab of metal film or layered materials. Generally it is hard to obtain images with resolution finer than the wavelength of light. Layered materials recently were proposed to realize the super-resolution imaging in the near field. In this SBIR program, we will carry out theoretical and experim ...

The purpose of this program is to provide a technology that enables the deployment of constellations of satellite based, coherent, RF sparse arrays. Such sparse arrays would have higher resolution than conventional approaches and would provide superior remote sensing capabilities at a fraction of today’s cost. The key enabling mechanisms are 1) the ability to accurately measure the distance be ...

Previous investigations into the geometrical and polarization properties of spiraled bend insensitive optical fiber layers indicate that coils made of many such layers can potentially facilitate inexpensive, high accuracy fiber optic gyroscopes (FOG). The proposed research will assess the theoretical and empirical behavior of both spiraled layers and coils through both modeling and experimentatio ...

The overall objective of this Phase II proposal is to determine the advantages of imidazenil over diazepam or midazolam as a potential anticonvulsant agent for the prophylaxis and for the emergency treatment of organophosphate nerve agent exposure. Therefore, we will compare the dose-dependent efficacy and anticonvulsant tolerance liability of imidazenil or midazolam for protecting rats against di ...