Award Data

Protection of deployed ground forces from disease-carrying insects requires the immediate and safe use of insecticides. Currently, control products are too slow to manage target pests and are unrealistic solutions under battlefield conditions. Vector-borne diseases transmitted by insects, such as malaria, dengue and leishmaniasis, are increasing worldwide and are more of a threat to our military f ...

The cost to maintain Moore’s law is growing exponentially with every generation of semiconductor device. To support the ever-increasing demand for smaller, faster, lower-power, and lower-cost microelectronic semiconductor devices, tools enabling faster and lower-cost research and development are required. Current development tools are only capable of achieving one data point per wafer. The goal ...

Adenoviruses are a frequent cause of epidemic acute respiratory disease (ARD) in military recruit training centers and pose a significant threat to military readiness, especially during times of large mobilization. There are no FDA-licensed treatment options available for adenovirus infections. Under the SBIR phase I, PaxVax successfully re-developed research-grade Ad4 and Ad7 capsule vaccines wit ...

Burkholderia pseudomallei and Burkholderia mallei are highly pathogenic Gram - negative bacteria and the causative agents of melioidosis and glanders, respectively. These infections, which occur in humans and other animals, are endemic is wide regions of the developing world. This Phase II SBIR project will build on the success of our Phase I work, which established methods for generating monoclon ...

Bioassays employed to evaluate the diverse range of biomarkers associated with organ injury are time-consuming, costly and require multiple instruments/testing formats to reach a diagnosis (i.e. fluorescence-based capture, ELISAs, PCR, etc.). Individually, these platforms are incapable of predicting the onset of irreversible organ tissue injury (e.g. kidney, liver, heart and lung). If a single mul ...

Typical handheld medical ultrasound array probes are not well suited to point of injury care or attended casualty evacuation vehicles due to their bulky size and the requirement that the device be held in the hand of the medic. Portable ultrasound systems are available that allow for improved mobility, but a truly wearable portable system has not yet been realized. This proposal seeks to develop a ...

Current methods for stem cell isolation are time-consuming, costly, and labor-intensive, and ill-suited for point of care applications. To overcome these limitations, we propose to develop and demonstrate a high-throughput, non-invasive, microfluidic stem cell analyzer to enable a rapid isolation of high-quality stem cell products from clinically relevant samples. Our technology enables significan ...

including validation of cell extraction using standard assays and methods, and determination of the performance metrics. In addition, POC will develop a technology transition plan, FDA approval strategy, and a manufacturing plan for Phase III implementation.

ChromoLogic LLC (CL) is developing a Spectroscopic System for Therapeutic Drug Monitoring (THERASPEC), to meet the Armys need for a compact, robust system to assess the peak and trough therapeutic drug concentrations in blood to provide real-time TDM in fixed and field medical facilities. The THERASPEC prototype is based on spectroscopic

The vast majority of injuries in recent military conflicts have been inflicted by improvised explosive devices (IEDs) causing brain, extremities and genital-urinary injuries. Advanced computational models of IED blast physics and human body injury biomech