Award Data

Drug transport in the central nervous system is highly regulated by the Blood-Brain Barrier (BBB). Most medicines, including many for treating cancer, Alzheimer’s, and stroke, do not meet essential criteria, such as lipophilicity and low molecular weight, required for appreciable transport into the brain. However, endogenous peptides, such as insulin or transferrin, and certain monoclonal anti ...

Aerosols represent one of the more efficient methods to distribute biological and chemical agents throughout the atmosphere. Small aerosol droplets can be readily inhaled and easily penetrate deep into the lungs where they lodge in bronchial alveoli. Within the alveoli, chemical and biological agents can breach epithelial and endothelial cell layers and enter the bloodstream, where they cause da ...

Physical Sciences Inc. proposes to develop a software tool that is capable of defining the selection, composition, and placement of a constellation of standoff and point sensors for the protection of base facilities and forces deployed in the field. The constellation will be defined using an algorithm that optimizes the collective performance of the constituent sensors as a function of deployment ...

Physical Sciences Inc. proposes to continue development of a software tool that is capable of defining the selection and placement of a constellation of standoff and point sensors for the protection of base facilities and forces deployed in the field. The network will be defined using an algorithm that optimizes the collective performance of the sensors as a function of deployment need, geography, ...

Shelter enclosures for military working dogs in the event of a CB attack is a technology gap identified by the Joint Requirements Office. Important parameters to consider in the design of protective enclosures include low weight and size to minimize transport requirements; rapid setup; and accommodation of canine physiological and psychological comfort needs. The overall operational weight of th ...

Doctrine for employment of canines in a CBRN environment has evolved into a Collective Protection approach. Providing COLPRO has several very significant implications for Canine kennels and shelters: „X The outer surface of the structure must be CB agent impervious „X The outer surface of the structure must resist effects of the decontamination process „X The system must provide the animal ...

The primary objective of this effort is to design and develop a database management system (DBMS) and enable the integrated interpretation of the vast amounts of genomic and proteomic data in proper biological context. This DBMS will enable the development of diagnostic assays for human exposure to specific biological threat agents using an existing suite of systems biology tools. The DBMS design ...

Increases in amount and diversity of high-throughput data presents tremendous organizational and analysis challenges to researchers. Our objective in this effort is to address these challenges by designing and implementing a database management system (cipherDB) for the storage, management, analysis, and visualization of diverse biological data types. The Phase I design and implementation of ciphe ...

Spectral Sciences Inc. proposes to develop a prototype sensor for real-time trace-level analysis of complex multicomponent gas mixtures, specifically those containing Chemical Weapon (CW) agents and interferents. The instrument is based on high power quantum cascade lasers and photocoustic spectroscopy detection. Advanced detection algorithms take advantage of wide spectral coverage to provide hi ...

Physical Sciences Inc. proposes to develop an ultra low noise receiver module for direct detection LWIR LIDAR systems. The proposed receiver concept is compatible with emerging LWIR source technologies, e.g., optical parametric amplifier-based sources, as well as existing frequency-agile CO2 laser technology. The optical system will incorporate a rapidly-tunable Fabry-Perot interferometer (etalo ...