Award Data

The broader impacts of this Small Business Innovation Research (SBIR) Phase II project include an artificial intelligence technology designed to detect, identify, and determine levels of insect infestations in fields, providing a comprehensive decision support system in real-time.More efficient and precise insect monitoring would result in reduced chemical insecticide use by increasing the specifi ...

PROJECT SUMMARY/ABSTRACT This project proposes the development of technologies to provide low-cost monitoring of phenylalanine (Phe) levels in the blood by a simple, noninvasive, at-home urine test, in order to enable daily monitoring by individuals with phenylketonuria (PKU). Also known as phenylalanine hydroxylase deficiency, PKU is a rare inborn error of metabolism that occurs in the US at a fr ...

Mucopolysaccharidosis Type IVA (MPS-IVA; also called Morquio A Syndrome) is a rare genetic childhood disorder characterized by multi-systemic pathologies affecting the respiratory, cardiovascular, musculoskeletal, and central nervous systems leading to devastating quality-of-life and early death. The disease is due to deficiencies in N-acetylgalactosamine-6-sulfate sulfatase (GALNS) causing progre ...

ABSTRACT: Limited availability of fresh viable donor meniscal grafts reduces size-matching efficiency for meniscal allograft transplantation, restricting surgical accessibility and patient outcomes. Current preservation methods with retention of meniscal viability are inadequate. Fibrochondrocyte viability of transplanted menisci is accepted as one of the determinants of outcome following allograf ...

The broader/commercial impact potential of this Small Business Innovation Research (SBIR) Phase II project is to provide the food allergy patient community with a digital platform in order to improve care and support the implementation of emerging food allergy oral immunotherapy treatments. Today there are no cures for food allergies. Patients and their families are in constant fear of anaphylaxis ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is a novel process for providing customized prosthetic feet. Current prescription methods match patients with prosthetic feet designs based on the patient’s weight and level of physical activity. However, this method often neglects patient variabilities in terms of posture and walking gait a ...

7. Project Summary/Abstract A key component in any investigation of association and/or cause-effect relationships between the environment and health outcomes is the availability of accurate and precise models of exposure. Because the cost of collecting field data is often prohibitive, it is critical to incorporate any source of secondary information available to supplement sparse datasets. Seconda ...

ABSTRACT Background: In the U.S., over 200,000 girls and women age 0-49 are diagnosed with cancer annually. While improved diagnosis and treatment have led to increased survival rates (75% in premenopausal and 85% in childhood cancer patients), devastating side effects of cancer therapies include premature ovarian failure, infertility and menopause-related health risks. The current industrial stan ...

ABSTRACT We are developing and sensor, the X-VISUAL (X-ray Visualized Indicator for Screw bending Under Applied Load), to track fracture healing in canulated screws used to treat hip fractures. Hip fractures are a major public health concern with high in-hospital mortality rate. Approximately 330,000 hip fixation procedures are performed annually in the US. The average hip fixation hardware failur ...

Project Summary About 750,000 Americans and approx. 4.5 million patients worldwide have End-Stage Renal Disease (ESRD)1– 3. Aging population as well as rise in ESRD-related comorbidities are key factors in the anticipated rate of increase in patients with ESRD4. One of the primary causes for this high morbidity and mortality are the complications associated with maintaining a functioning vascula ...