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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. " Channel Multimodal Ultrathin Flexible SFE for cancer diagnosis and therapy"

    SBC: VERAVANTI INC.            Topic: 102

    Summary channel multimodal ultrathin flexible SFE for cancer diagnosis and therapy Minimally invasive optical imaging is being advanced by molecular probes that enhance contrast using fluorescence The applications in cancer imaging are very broad ranging from early diagnosis of cancer to the guiding of interventions such as surgery The high sensitivity afforded by wide field fluorescence i ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. "Modulation of Immune Checkpoints by Self Deliverable RNAi for Adoptive Cell Transfer"

    SBC: ADVANCED RNA TECHNOLOGIES LLC            Topic: 102

    Two of the most promising approaches to cancer immunotherapy are immune checkpoint blockade by monoclonal antibodies and the adoptive transfer of immune cells The recent successes in treating melanoma with anti PD and anti CTLA antibodies as well as the extremely successful application of T cells engineered to express the CAR receptor targeting CD to treat B cell lymphomas initiated a waterfal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. 2'-Fluorophosphophloretin (2FP)in the Treatment of Chronic Renal Failure

    SBC: DuoPhos            Topic: 400

    DESCRIPTION provided by applicant CKD chronic kidney disease is a progressive disease which is reported to affect of the worldandapos s population End stage renal disease ESRD is the fifth and final stage of CKD ESRD will affect million people worldwide in and more than Americans at a cost of more than $ billion in the U S alone Elevated serum phosphorus Pi is th ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. 3D living neural networks

    SBC: MEADOWLARK OPTICS, INC.            Topic: 101

    DESCRIPTION provided by applicant Mental disease including schizophrenia depression and autism spectrum disorders are still poorly understood although it is clear that they mostly represent cortical disorders The cortex is the primary site of higher mental functions yet despite extensive research there is still no unified theory of how the cortex works This is partly due to the fact that ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. 3D Virtual Slide System for Creation and Analysis of Focusable Digital Slides

    SBC: MICROBRIGHTFIELD, INC.            Topic: 101

    DESCRIPTION provided by applicant This project aims to develop a novel system Biolucida AT which will greatly enhance the use of array tomography the state of the art method for investigating synaptic plasticity at the molecular level in human postmortem research and animal models of psychiatric neurological and childhood developmental disorders Synaptic transmission is essential for centr ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. 99mTc-Tilmanocept for Sentinel Lymph Node Biopsy in Cervical Cancer Surgeries

    SBC: Navidea Biopharmaceuticals, Inc.            Topic: 102

    DESCRIPTION provided by applicant Navidea Biopharmaceuticals Navidea is seeking SBIR FastTrack grant support to investigate the clinical utility safety and efficacy of its new product mTc tilmanocept to identify sentinel lymph nodes SLNs during surgeries to remove early stage cervical cancers with the intent of improving patient outcomes and reducing post surgical morbidities in patie ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  7. 99mTc-Tilmanocept for Targeting Rheumatoid Arthritis (RA)-Driving Macrophages

    SBC: Navidea Biopharmaceuticals, Inc.            Topic: NIAMS

    DESCRIPTION provided by applicant Navidea Biopharmaceuticals is seeking SBIR Fast Track grant support for preclinical animal studies and a regulatory phase clinical study of the ability of mTc tilmanocept to identify skeletal joint inflammation due to rheumatoid arthritis RA RA is a chronic progressive systemic autoimmune disease characterized by skeletal joint inflammation If not ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. 99mTc-Tilmanocept Targeting of Cardiovascular Plaque in HIV Subjects

    SBC: Navidea Biopharmaceuticals, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Navidea Biopharmaceuticals is seeking support to progress efforts designed ultimately to determine if its diagnostic imaging agent mTc tilmanocept can be used to improve upon the identification of atherosclerotic plaques that are at high risk for near term rupture High risk atherosclerotic plaques are referred to as vulnerable plaques or thin cap fibroath ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. [18F]NAV4694 Imaging to Identify MCI Patients at Risk for Alzheimer's Dementia

    SBC: Navidea Biopharmaceuticals, Inc.            Topic: NIA

    DESCRIPTION provided by applicant Navidea Biopharmaceuticals is developing F NAV as a diagnostic imaging agent that can be used to visualize beta amyloid A plaques in the brains of living individuals Alzheimerandapos s disease is the leading cause of dementia All patients with dementia caused by Alzheimerandapos s disease have abundant A plaques in their brains There is a great need ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. A 3D particle tracking tool for next generation neuroscience microscopy

    SBC: DRVISION TECHNOLOGIES LLC            Topic: 101

    DESCRIPTION provided by applicant Time lapse D imaging of functional neural networks composed of many neurons connected through a complex web of synapses is a promising approach for gaining in depth understanding of how the central nervous system CNS works Using high speed confocal and fluorescence microscopy D sequences are routinely acquired to elucidate the development of functional ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health

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