Award Data

Chronic musculoskeletal pain creates a significant public health burden, and Veterans are disproportionately affected. The frequency and extent of co-occurrence of pain and PTSD, pain and Traumatic Brain Injury (TBI), all three conditions (Post-deployment Multi-symptom Disorder (PMD), and other multi-symptom syndromes can complicate and reduce the effectiveness of pain treatment. Furthermore, the ...

ABSTRACT SignificanceGravesdiseaseGDone of the most prevalent autoimmune diseasesis caused by stimulating autoantibodiesTSAbto the Thyroid Stimulating Hormone ReceptorTSHRresulting in hyperthyroidismCurrent methods for managing hyperthyroidism in GD target excess thyroid hormone secretion by ablation or removal of the thyroid or by blocking thyroid hormone synthesisEach of these therapies is assoc ...

Neonatal hypoxia ischemiaHIremains a major cause of acute perinatal brain injuryleading ultimately to neurologic dysfunction manifesting as cerebral palsymental retardationand epilepsyUnfortunatelycurrent treatment and prevention strategies in newborns are limitedThere are no currently available therapies to prevent treat and or attenuate brain damage in premature infants other than supportive car ...

Abstract Chronic kidney disease CKD is a progressive disorder affecting almost of the general population and this disease has shown a relentless growth over the past decades Patients with CKD have higher rates of hospitalization greater mortality shorter life expectancy and their healthcare costs are up to times more expensive than non CKD patients Thus treatments to slow halt ...

The pace of warfare is increasing rapidly with the emergence of numerous asymmetrical threats exhibiting complex interdependencies and shifting alliances. Never has it been more essential to acquire detailed tactical intelligence in time scales in hours ...

This program proposes to demonstrate an ultra-low power design methodology and circuits for digital logic employing advanced dynamic voltage scaling (DVS) for asynchronous NULL Convention Logic (NCL) circuits operating in sub-threshold to super-threshold voltage regimes. The power supply voltages of logic block partitions will be independently set by on-chip voltage controllers based on the data p ...

In order to maintain our nation’s technological superiority on air, sea and land, we must respond quicker to emerging threats and reduce the cost of major sensing platforms. Every DoD platform developed nowadays contains at least one sensor, whether it be RF, EO/IR, or acoustic. In fact, in a lot of recent developments, the platform is built around the sensor and exists only to support the senso ...

DESCRIPTION (provided by applicant): Pregnant women, particularly those from underserved populations, often have a multitude of behavioral risks that threaten positive pregnancy and birth outcomes, as well as the future health of mother and baby. This application represents innovative research for impacting the promotion of healthy behaviors among pregnant women. The objective is to develop and te ...

DESCRIPTION (provided by applicant): A Phase I SBIR program of preclinical development is proposed focusing on the development of an active specific immunotherapeutic called Cellarium for treatment of glial cell-based cancers. Successful completion of this project will establish the minimum level of therapeutic feasibility and lead to further development of the vaccine in preparation for f ...

Investment castings have well served both the military and commercial markets in such areas as waveguides and splitters for microwave applications, and for connectors, housings, heat sinks and mechanical parts for electronics, optical, instrumentation, and medical devices. Tomorrow's higher RF millimeter wave and communications electronics products, and more compact optical, instrumentation and m ...