Award Data

DESCRIPTION: The HIV pandemic is one of the greatest public health challenges in history. It is estimated that 33 million people are living with HIV and 2.7 million of those are newly infected In a number of developed countries, the risk of death associated with HIV-1 infection has sharply declined due to the use of highly active antiretroviral therapy (HAART). Unfortunately, the rate of new HIV i ...

DESCRIPTION provided by applicant The proposed project will further develop marketable ELISA and lateral flow immunoassay diagnostics LFI in both monoplexed and multiplexed formats for the NIAID category A BSL filoviruses and will drive pre clinical development and validation for these diagnostics These assays will be used for diagnosis of Ebola virus EBOV Sudan virus SUDV and Marbu ...

DESCRIPTION (provided by applicant): Malaria causes 500 million clinical cases and gt 1 million deaths annually, is responsible for a loss of gt 1.3% of GDP in Africa annually, and is a serious concern for travelers and the military. A vaccine would be the ideal preventive and is perhaps the only intervention that could facilitate eradication of the disease. When attenuated P. falciparum sporozoi ...

Project Summary/Abstract According to the ADA, 25.8 million children and adults have diabetes. Diabetics have an increased risk of complications such as heart disease and are prone to impaired wound healing. A major cause of morbidity and hospitalizationis diabetic foot ulceration (DFUs) that may result in infection, gangrene, amputations requiring prolonged hospitalization, costly treatments, an ...

DESCRIPTION provided by applicant According to the ADA million children and adults have diabetes Diabetics have an increased risk of complications such as heart disease and are prone to impaired wound healing A major cause of morbidity and hospitalization is diabetic foot ulceration DFUs that may result in infection gangrene amputations requiring prolonged hospitalization costly tr ...

DESCRIPTION (provided by applicant): Breast cancer is the most prevalent malignancy among women. Its awareness and screening have resulted in the majority of breast cancers being diagnosed in the early-stage, for which breast conservation therapy (BCT) has become the standard of care. BCT consists of a lumpectomy followed by 6-8 weeks of radiation therapy, mostly irradiating whole breast. Althoug ...

DESCRIPTION provided by applicant Encephalitis and meningitis are potentially fatal diseases defined by acute inflammation of the brain or protective membranes covering the brain and spinal cord These diseases can be caused by viruses bacteria fungi parasites or amoeba and disproportionately affect children the elderly or the immunocompromised Viruses are the most common cause of enceph ...

DESCRIPTION provided by applicant Human rhinoviruses HRV are the leading cause of common colds and virus induced exacerbation of asthma and chronic pulmonary diseases In addition HRV can cause severe lower respiratory tract infections in children the elderly and immune compromised patients The economic burden of the common cold is estimated to be about $ B each year in the US in terms o ...

DESCRIPTION (provided by applicant): A two-phase study is planned to validate whether functional breast imaging with a dedicated breast PET device could detect and confirm breast cancer multifocality and/or multicentricity prior to surgery. Surgeons ar

DESCRIPTION (provided by applicant): Phase I Ovarian cancer is the fifth leading cause of cancer death among U.S. women and has the highest mortality rate of all gynecologic cancers, with 23,400 new cases and 13,900 deaths projected in 2001. Screening