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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Clinical Human Cell Production System for Broad Use

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): As a result of growing evidence of their therapeutic potential in cancer, infectious diseases, and tissue repair, there is an enormous increase in the research and discovery of cell-based medical treatments that require cultured cells. A large unmet need exists for a cost-effective system that will facilitate the development of clinical cell production capabil ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  2. Enhanced Tumor Antigen Priming of Dendritic Cell Vaccine

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by the applicant): Dendritic cells have been shown to initiate, regulate, and direct cytolytic T-cell-mediated immune responses against tumor antigens in human patients. Recent clincal trials have demonstrated induction of clinically significant immune responses against malignant diseases using DCs primed ex vivo with autologous tumor antigens including tumor cell lysates. E ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  3. Automated Perfused Culture Process for Adult Stem Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Adherent mesenchymal cell populations derived from bone marrow (BM) have the capability of differentiating into multiple cell lineages in vitro and in vivo. The potential use of these populations, referred to as marrow stromal cells (MSC), in clinical applications to treat nonhematopoietic disorders is being intensely investigated. Ex vivo expansion is being us ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  4. Clinical-scale Production of Osteoprogenitor Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Due to morbidity and limited amounts of material, alternatives to autologous grafts for bone repair are desirable. Mixtures of marrow stromal cells (MSC) and carrier matrices are known to augment bone repair. Increasing the number of MSC through ex vivo expansion may significantly increase the amount and rate of new bone formation. In this proposal, the abilit ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  5. Automated Large-Scale Production of Endothelial Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Treatment of ischemia by administration of bone marrow (BM)-derived endothelial progenitor cells (EPC) or ex vivo expanded EPC populations has been shown to enhance vascular regeneration in animal models and in clinical trials. For cell therapy to be practical in a clinical setting, simple, efficient, GMP compliant methods for cell production are needed. Aastro ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  6. Rapid, Low-Cost, Reformable Tooling for Prototyping and Short-run Manufacturing of Advanced Composite Structures

    SBC: 2PHASE TECHNOLOGIES, INC.            Topic: N/A

    A major obstacle for BMD systems to the introduction of new structures and designs using high-performance composites is the time and cost of the tooling required both to prototype and test new components and to transfer accepted designs to manufacturing.The development of reformable, reusable tooling based on 2Phase Technologies' patented state-change materials will reduce the time, cost and effor ...

    SBIR Phase I 2003 Department of DefenseMissile Defense Agency
  7. A Fail-Safe Controllable Magneto-Rheological Fluid Smart Pad/Damper System for Submarine Based Weapon Shock and Vibration Mitigation

    SBC: ADVANCED MATERIALS & DEVICES            Topic: N/A

    An innovative tunable vibration absorber (TVA) concept was developed in the Phase I feasibility study. This design was selected among others to be developed in full scale in Phase II and Phase II Option based on a detailed theoretical modeling, smallprototype test results, and a cost analysis, which were conducted in Phase I.In Phase II and Phase II Option a new generation of TVA utilizing a clas ...

    SBIR Phase I 2003 Department of DefenseNavy
  8. A Fail-Safe Controllable Magneto-Rheological Fluid Smart Pad/Damper System for Submarine Based Weapon Shock and Vibration Mitigation

    SBC: ADVANCED MATERIALS & DEVICES            Topic: N/A

    An innovative tunable vibration absorber (TVA) concept was developed in the Phase I feasibility study. This design was selected among others to be developed in full scale in Phase II and Phase II Option based on a detailed theoretical modeling, smallprototype test results, and a cost analysis, which were conducted in Phase I.In Phase II and Phase II Option a new generation of TVA utilizing a clas ...

    SBIR Phase II 2003 Department of DefenseNavy
  9. Synthetic Aperture Mobile Communications (SARCOM)

    SBC: ADVANCED MODULAR POWER SYSTEMS            Topic: N/A

    Improvements in channel capacity (i.e. bit rate) of mobile communication systems are important for extending their range and data throughput capabilities for current military and civilian applications and enable a number of new, highly marketable,applications. The objective of the program is the design, fabrication, and demonstration of an inexpensive, lightweight, 2-way (transmit/receive) mobile ...

    SBIR Phase I 2003 Department of DefenseArmy
  10. Personal Monitor to Detect Exposure to Toxic Agents

    SBC: ADVANCED SENSOR TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Advanced Sensor Technologies, Inc. (AST) proposes to continue its NIH funded Phase I efforts to develop a completely automated miniaturized device capable of monitoring different types of cholinesterases from a single drop of whole blood to determine the degree of exposure of an individual to organophosphate (OP) compounds or carbamates. This device will be ame ...

    SBIR Phase II 2003 Department of Health and Human ServicesNational Institutes of Health
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