Award Data

DESCRIPTION (provided by applicant): The principal aim of this project is to develop a resource library of very high-resolution computer models and imaging data sets of human skulls. This skull database project, which builds upon and is an extension of the Tooth Atlas project, will be the first phase of a complete, whole body, osteology library. As the imaging and computer technology advances, th ...

DESCRIPTION (provided by applicant): Despite the availability of newer antimicrobial agents, improved supportive care, and the introduction of an FDA approved adjunctive therapy for sepsis, (Xigris(r), drotrecogin alfa), the mortality rate for severe sepsis and septic shock of 30-60% remains high. Endacea, Inc. (Research Triangle Park, NC) approaches sepsis with a proprietary diagnostic/biomarker ...

DESCRIPTION (provided by applicant): Staphylococcus aureus is a significant human pathogen which can produce a variety of toxins, including the exotoxin, staphylococcal enterotoxin B (SEB). SEB is highly toxic in small doses, and the compact structure of this protein makes it resistant to heat and denaturation. The combination of toxicity and stability caused this toxin to be selected for weaponiz ...

DESCRIPTION (provided by applicant): Neurotargeting, LLC proposes to develop the technical support infrastructure as well as clinical tools for a commercial software product that will provide a global service for the medical community involved in deep brain stimulator (DBS) therapy. Specifically, this Phase I study will explore the use of a physiological atlas database that can interface with a nu ...

DESCRIPTION (provided by applicant): Over 215,000 people will be diagnosed in 2008 with bronchial carcinoma in the U.S. according to the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. Currently, asthma afflicts 22.9 million people in the U.S., and tracheomalacia is believed to afflict 3 million people in the U.S. In addition to these chronic or deadly ...

DESCRIPTION (provided by applicant): The general goal of this proposal is to assemble directed mutant gene sets quickly, cheaply, easily, and reliably. Mutant gene sets can share sub-assemblies, yielding savings of time, cost, and effort not possible if designed and assembled all as single genes. The approach is to build upon experience gained in Phase I, to extend and generalize methods of DNA de ...

DESCRIPTION (provided by applicant): Red Hill Studios, in collaboration Dr. Glenna Dowling of the University of California San Francisco School of Nursing and Dr. Sandra Radtke of San Francisco State University, propose to develop a computer-based therapeutic program for children with cerebral palsy (CP). The computer game will include movements that are based on existing therapy methods that hav ...

DESCRIPTION (provided by applicant): Inadequate sensitivity and specificity of currently-used imaging methods for cancer screening of the breast motivates the development of new modalities capable of adding diagnostic information. EMAI (electromagnetic acoustic imaging) is a novel imaging method which exploits tissue electrical conductivity and acoustic properties for the purposes of cancer detect ...

DESCRIPTION (provided by applicant): Type 2 diabetes mellitus (T2D) affects 18 million Americans, with national healthcare and lost productivity costs exceeding 100 billion per year. T2D begins as a state of compensated insulin resistance; frank disease develops when approximately 50% of insulin-producing pancreatic islet -cells of affected individuals undergo cell death. Numerous recent studies ...

DESCRIPTION (provided by applicant): Recent cancer therapies have focused on using biologics to target specific signal transduction pathways implicated in the tumor development or progression. For example, recombinant fusion proteins consisting of the extracellular domain of the immunoregluatory proteins and the constant (Fc) domain of immunoglobulin (IgG) represent a growing class of protein ther ...