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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Microcapillary Quartz Sensors for Screening Injectability of High Concentration Protein Formulations

    SBC: Qatch Technologies, LLC            Topic: None

    The objective of this SBIR Phase I proposal is to determine the feasibility of viscosity characterization of high concentration protein formulations (HCF) by QATCH’s microcapillary quartz technology. HCFs are non-Newtonian fluids with shear-thinning behavior and they are administered to patients by subcutaneous or muscular injections. The injectability of HCFs depends on the viscosity at high-sh ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  2. Nanomachine Device for Semiconductor Process Control Monitoring

    SBC: Xallent LLC            Topic: None

    Conventional characterization and test methods are increasingly ineffective when applied to structures less than 100 nanometers, causing challenges across R&D, process control and failure analysis. An increasing number of subtle defects become prominent drivers of failure as device size and operating margins decrease, e.g., processing anomalies in thin gate oxides, substrate problems related to do ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  3. Continuous Learning for Additive Manufacturing Processes Through Advanced Data Analytics

    SBC: Senvol LLC            Topic: NA

    Additive manufacturing (AM) is a promising manufacturing technique for end-use parts that can solve challenges for American manufacturers in many industries, e.g. aerospace, defense, automotive, energy, and healthcare. However, despite the potential that AM offers, the rate of AM adoption in industry is very slow. This is because AM suffers from low repeatability and quality consistency issues, wh ...

    SBIR Phase I 2018 Department of CommerceNational Institute of Standards and Technology
  4. SWIFT ActiveScreener research and development of an intelligent web based document screening system

    SBC: Sciome LLC            Topic: NIEHS

    Project Summary More than systematic reviews are performed each year in the fields of environmental health and evidence based medicine with each review requiring on average between six months to one year of effort to complete In order to remain accurate systematic reviews require regular updates after their initial publication with most reviews out of date within five years In the sc ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Engineering Hair Follicles in Vascularized D Skin Models

    SBC: Rapunzel Bioscience, Inc.            Topic: NIAMS

    ABSTRACT Each year more than one million patients are hospitalized in the U S for significant skin loss due to thermal and pressure injuries chronic diabetic ulcers or genetic skin diseases The ability to generate engineered human skin equivalents HSEs has provided a promising and effective therapy for these patients However currently available HSEs still have various limitations including ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Implantable iontophoresis chemotherapy delivery device for direct infusion of gemcitabine into pancreatic adenocarcinoma Device development and First in Human clinical trial

    SBC: Advanced Chemotherapy Technologies            Topic: 102

    PROJECT SUMMARY Advanced Chemotherapy Technologies ACT has developed a proprietary implantable iontophoretic device that facilitates the infusion of chemotherapy agents directly into a cancer tumor minimizing toxic exposure to the vascular system and other organs ACT is focusing specifically on treating pancreatic cancer with gemcitabine for this proposal Pancreatic cancer has a five year sur ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Isochoric Pressure Assisted Vitrification of Testicular Tissue and Whole Testes

    SBC: Sylvatica Biotech, Inc.            Topic: NICHD

    This program aims to develop a novel method for cryopreserving human testicular tissue and whole testes which can also be applied to ovarian tissue and gonadal preservation and ultimately any cells tissues and whole organs This multi pronged approach builds on recent advances in machine perfusion nature inspired cytoprotection strategies and non toxic cryoprotectant solutions combining them ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Innovative Tools for Three Dimensional Traction Force Microscopy of Single Cells

    SBC: SIMMETRIX INC.            Topic: 102

    Project Summary Tractions exerted by individual cells on their surroundings play a critical role in mechanical events in biology such as tissue contraction folding cell shape changes or cell movements and in many basic cellular functions such as biochemical signaling proliferation and differentiation These processes are in turn implicated in the progression of diseases like cancer atherosc ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Novel PhageLock assay to measure hepcidin for clinical monitoring

    SBC: AFFINERGY, LLC            Topic: 400

    SUMMARY ABSTRACT Hepcidin is the peptide hormone responsible for regulating circulating iron concentrations Overexpression of hepcidin results in severe iron deficiency and anemia whereas hepcidin deficiency leads to iron overload Not surprisingly abnormalities in hepcidin production and circulating concentrations are highly correlated with various disease states such as renal disease cancer ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Ultrasound Based Device to Guide Treatment of Graft Versus Host Disease Using Skin Elasticity as a Biomarker

    SBC: Microelastic Ultrasound Systems, Inc.            Topic: 102

    Ultrasound Based Device to Guide Treatment of Graft Versus Host Disease using Skin Elasticity as a Biomarker ABSTRACT Sclerotic chronic graft versus host disease cGVHD develops in of allogenic Human Stem Cell Transplant HCT recipients and is associated with significant morbidity and mortality GVHD is treated with immunosuppression which puts patients at severe risk of infection ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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