Award Data

Wave Computation Technologies, Inc. (WCT) proposes to develop a new multiscale solver for electromagnetic field/circuit co-simulation. This solver combines three efficient electromagnetic field algorithms, (a) the spectral element time-domain (SETD) metho

DESCRIPTION (provided by applicant): Despite the availability of newer antimicrobial agents, improved supportive care, and the introduction of an FDA approved adjunctive therapy for sepsis, (Xigris(r), drotrecogin alfa), the mortality rate for severe sepsis and septic shock of 30-60% remains high. Endacea, Inc. (Research Triangle Park, NC) approaches sepsis with a proprietary diagnostic/biomarker ...

DESCRIPTION (provided by applicant): Staphylococcus aureus is a significant human pathogen which can produce a variety of toxins, including the exotoxin, staphylococcal enterotoxin B (SEB). SEB is highly toxic in small doses, and the compact structure of this protein makes it resistant to heat and denaturation. The combination of toxicity and stability caused this toxin to be selected for weaponiz ...

DESCRIPTION (provided by applicant): Neurotargeting, LLC proposes to develop the technical support infrastructure as well as clinical tools for a commercial software product that will provide a global service for the medical community involved in deep brain stimulator (DBS) therapy. Specifically, this Phase I study will explore the use of a physiological atlas database that can interface with a nu ...

DESCRIPTION (provided by applicant): Recent cancer therapies have focused on using biologics to target specific signal transduction pathways implicated in the tumor development or progression. For example, recombinant fusion proteins consisting of the extracellular domain of the immunoregluatory proteins and the constant (Fc) domain of immunoglobulin (IgG) represent a growing class of protein ther ...

DESCRIPTION (provided by applicant): The long term objective of the proposed studies is to develop a monoclonal antibody that can be administered safely to patients with diabetes that will inhibit atherosclerosis. Insulin-like growth factor-I has been implicated in the initiation of the proliferative phase of atherosclerotic lesion development but inhibiting IGF-I receptor activity may lead to tox ...

Current aircraft design approaches incorporate the use of many high fidelity models for point solutions of individual disciplines. Sophisticated model integration techniques are not yet readily available and a significant amount of individual discipline stovepiping exists. Individual handoffs of point solutions between disciplines often results in repeated individual data interpretations.  These ...

The proposed STTR Phase I study is aimed at exploring lightweight and multi-layer materials towards enhancing their armor performance. Different Al alloys will be assembled into a two-layer configuration with good metallic bond between inter-layers. 2139-T8 Al alloy evolved by efforts of Alcan and the Army Research Laboratory will be selected as one of the layers in the laminated assembly. 5083, 7 ...

Development of a compliant microfabricated heat exchanger to work with thermoelectric devices as a means of power generation for hypersonic vehicles is proposed. Polymer-based materials provide to provide compression on the thermoelectric module, to ensure optimal thermal contact, while allowing for compliance to allow for the change in materials expansion without exceeding the failure point of th ...

DESCRIPTION (provided by applicant): The American Cancer Society estimates that a total of 240,430 new breast cancers were diagnosed in 2007 (178,400 new cases of invasive breast cancer, and 62,030 new cases of in situ breast cancer). Approximately 180,000 of these patients undergo breast conserving surgery (BCS), also called lumpectomy. Multiple recent studies show that a staggering 20-70% of the ...