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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. The Impact Integrated Data System for Quality and Outcomes Tracking of Prevention Programs

    SBC: 3-C Institute for Social Development, Inc.            Topic: 104

    Abstract There has been substantial progress in developing evidence based prevention programs EBPPs for preventing risky behaviors and promoting positive mental health outcomes for youth Unfortunately EBPP adoption quality implementation long term sustainability and scalability in real world service settings continues to lag far behind jeopardizing the ability to achieve the intended broad ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Functional Tissue Engineering for Cartilage Repair

    SBC: Cytex Therapeutics, Inc.            Topic: NIA

    Abstract It is estimated that only about of young patients suffering from!activity limiting hip osteoarthritis OA choose to undergo traditional hip replacement surgery This low percentage is attributed to the shortened projected lifetime of hip implants for active patients and the subsequent need for revision surgeries that are plagued with higher complication rates and overall decreased ef ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Ultrasound Based Device to Guide Treatment of Graft Versus Host Disease Using Skin Elasticity as a Biomarker

    SBC: Microelastic Ultrasound Systems, Inc.            Topic: 102

    Ultrasound Based Device to Guide Treatment of Graft Versus Host Disease using Skin Elasticity as a Biomarker ABSTRACT Sclerotic chronic graft versus host disease cGVHD develops in of allogenic Human Stem Cell Transplant HCT recipients and is associated with significant morbidity and mortality GVHD is treated with immunosuppression which puts patients at severe risk of infection ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Creation of animal models of mitochondrial DNA disease for translational research applications

    SBC: Enzerna Biosciences LLC            Topic: 400

    Mitochondria are the principal generators of cellular ATP by oxidative phosphorylation which links electron transport via Complexes I through IV to production of ATP via ATP synthase Over pathogenic human mitochondrial DNA mtDNA mutations associated with diseases ranging from cardiomyopathy to juvenile blindness have been identified Collectively millions are affected by mtDNA disease fo ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a POEGMA Aptamer rapid onset anticoagulant that eliminates antigenicity to anti PEG antibodies

    SBC: Gateway Bio, Inc.            Topic: NHLBI

    ABSTRACT The objective of this STTR proposal is to reformulate a promising PEG aptamer rapid onset anticoagulant ROA by applying a novel PEG like POEGMA polymer brush technology capable of eliminating anti PEG antigenicity The importance of this proposal is highlighted by the early termination of a recent Phase III clinical trial of the original PEG aptamer conjugate in which severe allergic ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. BurntOut Role Play Simulation for Building Medical Student Resiliency

    SBC: Clinical Tools, Inc            Topic: 400

    We propose to produce a simulation experience to ensure that clinical year medical students are prepared for have coping strategies to deal with and are more resilient to the stresses and challenges that await them as they transition to clinical practice and learning in a clinical environment The experience will guide institutional level change by anonymously communicating studentsandapos conc ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A D osteoarthritis model targeting patient populations with high risk genetic polymorphisms

    SBC: Cytex Therapeutics, Inc.            Topic: NIAMS

    Abstract Osteoarthritis OA is a degenerative joint disease that affects an estimated million adults in the United States and results in an economic burden of over $ billion per year Although the burden of OA is immense current non surgical treatments are only palliative and no disease modifying OA drugs DMOADs presently exist to address the problem This lack of success in identifying ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. AML MutationCounter a tool to detect residual and recurrent leukemia

    SBC: Asystbio Laboratories, LLC            Topic: 102

    Abstract AsystBio LLC proposes to market a molecular tool kit called AML MutationCounter to count somatic mutations in genes that contribute to the development of acute myeloid leukemia AML We have developed a set of reagents and computer programs for application of next generation sequencing to count AML gene mutations The tool kit is versatile and can be used with either of the two major DNA ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Whole organ bioreactor with integrated nondestructive D molecular imaging

    SBC: Sonovol, Inc.            Topic: NHLBI

    Abstract Significance Donor tissue shortage remains a critical problem in lung transplantation Recent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffolds These scaffolds created from the donor s tissue become functionalized after recellularization with a patient s own cells However translation of whole lung de ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Optical fiber integration into Bi2Sr2CaCu2Ox/Ag/AgX and (RE)Ba2Cu3Ox superconducting coils

    SBC: Lupine Materials and Technology, Inc.            Topic: 27f

    High-temperature superconductors (HTS) are a vital technology for future particle accelerators, motors, generators and other electric power systems, fusion reactors, and many other medical and defense applications requiring high magnetic fields. One remaining limiting factor limiting to the implementation of HTS systems is the lack of adequate sensors to monitor the temperature and strain states o ...

    STTR Phase II 2017 Department of Energy

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