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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Development of an Osteoinductive Spinal Fusion Implant for Enhanced Fusion Rates

    SBC: Evoke Medical, LLC            Topic: NIAMS

    PROJECT SUMMARY The objective of this Phase II SBIR is to test the safety and efficacy of an osteoinductive lumbar spinal fusion implant in an ovine modelIn preliminary worklower impedance piezoelectric materials that generate power for direct currentDCelectrical stimulation applications were manufactured and electromechanically characterizedIn an osteoinductive spinal fusion implant designan insu ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. Targeting Bioenergetic Flux for Alzheimer's Disease Management

    SBC: Aerobyx LLC            Topic: NIA

    PROJECT SUMMARYBioenergetic dysfunction occurs in Alzheimer s diseaseADand represents a potential AD therapeutic targetFor these reasonswe founded AerobyxLLCThe goal of Aerobyx is to develop drugs that specifically target brain bioenergetic fluxesand to use those drugs to treat persons with ADOur strategy emphasizes fundamental biochemical principles such as the law of mass actionand additionally ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. SBIR Phase II: Universal electronic platform and system for rapid (direct from sample) phenotypic Antibiotic Susceptibility Testing (AST)

    SBC: Impedx Diagnostics Inc.            Topic: BM

    This SBIR Phase I project addresses the need to reduce the time associated with conducting tests currently used to establish targeted antibiotic (and dose) to treat infections. Sepsis and septic shock are one of the leading contributors to death in US Hospitals, responsible for 250,000 deaths annually (estimated at 30-50% of all hospital deaths). To combat these high death rates, time is of the es ...

    SBIR Phase II 2018 National Science Foundation
  4. Affinity reagents for the sub-fractionation of specific exosomal populations

    SBC: Nectagen, Inc.            Topic: 400

    The goal of this Phase I SBIR project is to develop affinity reagents useful for the sub fractionation of specific exosomal populationsBecause exosomal makeup and cargo reflect the typedevelopmental stageand the disease state of the cells they are shed fromthey are attractive targets for non invasive diagnosticsExosomes are also being investigated for therapeutic applications such as vaccines and ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Development of a Wearable Band-Aid Biosensor System for Alcohol Monitoring

    SBC: Design-Zyme LLC            Topic: 450

    Project Abstract The goal of this Phase I SBIR is to develop a non invasive wearable dermal deviceBand Aidcapable of extracting and sensing ethanol from interstitial space using reverse iontophoresisnot sweat!and transmitting the results wirelessly to a Bluetoothcapable deviceThe proposed band aid patch will be easily applied to the epidermisand will provide monitoring of ethanol levels in a cost ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. A coupled oil extraction/distillation-biochar system to utilize Eastern red cedar in value-added products and provide environmental benefits

    SBC: BLUE EARTH LLC            Topic: 81

    Woody encroachment of grasslands has led to wildfires that have recently destroyed homes and adversely affected rural communities. Eastern red cedar (ERC) is a major culprit in woody expansion and causes habitat fragmentation for upland bird and other wildlife species, with adverse effects on infiltration of precipitation, induced changes to plant species composition that degrade habitat and reduc ...

    SBIR Phase I 2018 Department of Agriculture
  7. Quantifiable Thermal Therapy Using Magnetic Resonance Thermometry Imaging

    SBC: NeoTherma Oncology Inc.            Topic: 102

    Pancreatic Ductal AdenocarcinomaPDACis the third leading cause of cancer related death in the United Statesand is characterized with dismal odds due to advanced disease at late stage diagnosisTheyear survival rate ranges fromfor patients with non resectable diseaseof patientstofor patients with resectable tumorsandltof patientsPDAClike most solid tumorsis highly hypoxicresulting from both poor oxy ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Isolation and Identification of Prebiotic Nutrient Components

    SBC: Design-Zyme LLC            Topic: NIA

    ABSTRACT Studies of the microbiome of older individuals has shown greatly reduced numbers of known beneficial bacteria coinciding with a greater presence of potentially detrimental bacterial strainsNot surprisinglythe decrease in beneficial microbes coincides with a loss of anti inflammatory activity and genes associated with short chain fatty acid productionThis age related decline in the gut mic ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Microfluidic Magnetic Anisotropic Array for High-throughput Isolation of Extracellular Vesicles and Exosomes

    SBC: Clara Diagnostics, Inc.            Topic: 396

    ABSTRACT Tumor derived circulating exosomes has been emerging in fundamental cancer researchclinical diagnosis and monitoring of treatment responsesHoweverthe specific preparation of enricheddistinct exosome populations is still challengingCurrentlythe most common procedure for purifying exosomes involves a series of high speed ultracentrifugation steps in order to remove cell debris and pellet ex ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Over-the-Wire Device for Immediate and Complete Peripheral Artery Occlusion

    SBC: Metactive Medical, Inc.            Topic: NHLBI

    ABSTRACT Metactive Medical is developing the Blockstent Microcatheteran innovative medical device for endovascular occlusion of peripheral arteries and veinsThe device uses an expandabledetachablegold metal balloon that can be delivered using a highly flexiblelow profileover thewire microcatheteraddressing an unmet medical need for a device that is easy to use and delivers immediatecompleteand las ...

    SBIR Phase II 2018 Department of Health and Human Services

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