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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Novel method to create knockout rats using endonucleases and spermatogonial stem


    DESCRIPTION provided by applicant The laboratory rat is a preferred rodent model in pre clinical drug studies Their larger size facilitates procedures otherwise difficult in mice includng studies using instrumentation blood sampling and surgeries and allows for ten times the amount of tissue collection Although rats are often more suitable than mice for pharmacological toxicological phy ...

    SBIR Phase II 2014 Department of Health and Human Services
  2. Cryopreservation of Anopheles Embryos

    SBC: SANARIA INC.            Topic: R

    DESCRIPTION provided by applicant The ideal most effective tool for eliminating Plasmodium falciparum Pf the causative agent of of all malaria deaths is a highly effective vaccine that prevents blood stage infection and thereby prevents both disease and transmission Sanariaandapos s goal is to develop and commercialize a Pf sporozoite SPZ vaccine that prevents Pf blood stage infect ...

    SBIR Phase II 2014 Department of Health and Human Services
  3. An HIV Vaccine Strategy Based on Priming with rVSV Expressing FLSC

    SBC: PROFECTUS BIOSCIENCES, INC.            Topic: R

    DESCRIPTION Based on the prevailing evidence we believe that a highly effective vaccine for HIV prophylaxis must induce long lasting broadly cross reactive antibody responses to envelope that exhibit antiviral activity as well as multi antigen polyfunctional CD and CD T cell responses that produce antiviral chemokines and cytokines and are possibly biased towards an effector memory phenot ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Recombinant antigen diagnostics for filoviruses


    DESCRIPTION provided by applicant The proposed project will further develop marketable ELISA and lateral flow immunoassay diagnostics LFI in both monoplexed and multiplexed formats for the NIAID category A BSL filoviruses and will drive pre clinical development and validation for these diagnostics These assays will be used for diagnosis of Ebola virus EBOV Sudan virus SUDV and Marbu ...

    SBIR Phase II 2014 Department of Health and Human Services
  5. Development of the first HRV vaccine


    DESCRIPTION provided by applicant Human rhinoviruses HRV are the leading cause of common colds and virus induced exacerbation of asthma and chronic pulmonary diseases In addition HRV can cause severe lower respiratory tract infections in children the elderly and immune compromised patients The economic burden of the common cold is estimated to be about $ B each year in the US in terms o ...

    SBIR Phase II 2014 Department of Health and Human Services
  6. Improving Accuracy and Accessibility of Early Autism Screening

    SBC: Total Child Health, Inc.            Topic: 103

    DESCRIPTION provided by applicant Autism is prevalent in children and impairing but early intervention has been shown to improve outcomes prompting recommendations for screening at both two year and month health check ups Detection of autism early is crucial but accurate screening tools have been elusive In Phase II a practical method of improving accuracy of M CHAT the most widel ...

    SBIR Phase II 2014 Department of Health and Human Services
  7. Biological vector control reducing arboviruses, including Dengue and Chikungunya

    SBC: MOSQUITOMATE, INC.            Topic: NIAID

    DESCRIPTION provided by applicant In the absence of effective approved drugs or vaccines vector control remains the only means of intervention for many against mosquito borne diseases This problem grows more complex with the recent establishment of multiple exotic mosquito species and mosquito borne pathogens Furthermore changing climate conditions are predicted to alter the traditional ra ...

    SBIR Phase II 2014 Department of Health and Human Services
  8. Diagnostic array for aseptic encephalitis


    DESCRIPTION provided by applicant Encephalitis and meningitis are potentially fatal diseases defined by acute inflammation of the brain or protective membranes covering the brain and spinal cord These diseases can be caused by viruses bacteria fungi parasites or amoeba and disproportionately affect children the elderly or the immunocompromised Viruses are the most common cause of enceph ...

    SBIR Phase II 2014 Department of Health and Human Services
  9. Infant Assessment of Early Communication Risk Factors: The ISCBS (formerly ECBS)


    DESCRIPTION provided by applicant Effective early intervention depends on reliable identification of risk for communication impairments as soon as possible Established infant risk factors for communication impairments include poor turn taking gestures receptive language commenting symbolic play and speech Although these risk factors can be detected by mos and reliably predict late ...

    STTR Phase II 2014 Department of Health and Human Services
  10. Catheter for Large Volume Intraparenchymal Brain Therapies

    SBC: TWIN STAR TDS, LLC            Topic: 105

    DESCRIPTION provided by applicant Neurodegenerative and malignant diseases of the central nervous system affect millions of Americans These diseases are often devastating and difficult to treat and effective drug delivery remains a significant challenge Infusion of drugs nto the brain parenchyma using convection enhanced delivery CED allows direct treatment of lesions circumventing the bl ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health

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