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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Induction of Donor Tolerance in Renal Transplants

    SBC: REGENEREX, LLC            Topic: NIDDK

    DESCRIPTION: Renal transplantation is the preferred therapeutic approach for end organ failure. However, the chronic use of immunosuppressive agents is critical to prevent rejection. The drugs are costly ( 15,000-25,000/year) and have significant toxicities including opportunistic infection, an increased rate of malignancy, nephrotoxicity, and other end organ damage. The induction of donor-specifi ...

    STTR Phase II 2011 Department of Health and Human Services
  2. Bacterial-Induced Sepsis: A New Treatment Strategy

    SBC: TARGETED GENE DELIVERY, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Sepsis is a prevalent and life-threatening medical condition characterized by development of a dysregulated inflammatory immune response and associated tissue damage. This dysregulated inflammatory response is initiatedby activation of Toll-Like receptor (TLR) signaling in response to bacteria and/or bacterial products, such as LPS. Current treatments are limit ...

    SBIR Phase II 2011 Department of Health and Human Services
  3. Development of a Yellow Fever Vaccine for Vulnerable Population

    SBC: NAJIT TECHNOLOGIES, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Yellow fever virus (YFV) was at one time endemic in the United States and represents a mosquito-borne emerging/re-emerging human pathogen that causes up to 20% mortality. The current live attenuated YFV vaccine was developed in 1936 and following the development of a virus seed lot system, it has not been modified or otherwise improved in over 50 years. Accordi ...

    SBIR Phase II 2011 Department of Health and Human Services
  4. Naloxone Nasal Spray Development

    SBC: ANTIOP, INC.            Topic: NIDA

    DESCRIPTION: The following proposal is a follow-on Phase 2 b application from our initial proposal (1-R42 DA 030001). U.S. drug overdose deaths, mostly commonly from opioids, now exceed deaths from automobile accidents. There is a significant unmet medical need to provide additional pharmacologic options for treatment of opioid overdose. Emergency medical service personnel would prefer a non- inj ...

    STTR Phase II 2013 Department of Health and Human Services
  5. Advanced Breakwater And Causeway Ultramarine System (ABACUS) Development

    SBC: Quantum Engineering Design, Inc.            Topic: N092156

    Expansion of the Advanced Breakwater And Causeway Ultramarine System (ABACUS) research and development work accomplished under the Phase II Basic and Options 1 & 2 programs to full scale prototype systems and large scale demonstration models for both Seabasing and ship-to-shore logistics support operations. The ABACUS family of systems support a) the mitigation of waves about Sealift ships at the ...

    SBIR Phase II 2014 Department of DefenseNavy
  6. Preclinical development of novel small molecule malaria drugs that overcome drug

    SBC: DESIGNMEDIX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The worldwide health problem created by malaria has been made more difficult by the spread of drug resistant parasites We have developed an orally available and inexpensive class of novel drugs that act against both chloroquine resistant and chloroquine sensitive malaria This project carries on preclinical development of a drug candidate that has been select ...

    STTR Phase II 2014 Department of Health and Human Services
  7. A human cytomegalovirus-based immunotherapy for HIV-1

    SBC: TOMEGAVAX, INC.            Topic: NIAID

    DESCRIPTION The ultimate goal of this project is to develop an immunotherapy for human immunodeficiency virus HIV based on a spread deficient cytomegalovirus CMV derived vaccine expressing andquot tailoredandquot antigens designed for maximal coverage of clade B epitopes In non human primate models rhesus CMV vectored vaccines demonstrated unprecedented protection against highly virulent ...

    SBIR Phase II 2014 Department of Health and Human Services
  8. A CD8+ T cell diagnostic to identify children with pulmonary tuberculosis

    SBC: ViTi, Inc            Topic: NIAID

    DESCRIPTION provided by applicant Tuberculosis TB disease which results from infection with Mycobacterium tuberculosis Mtb is a leading cause of infectious morbidity and mortality in children andlt years old worldwide In TB endemic regions in which the vast majority of the worldandapos s annual million adult cases of TB disease reside children andlt years old account for ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  9. SapC-DOPS Nanovesicles for Treating Glioblastoma Multiforme

    SBC: BEXION PHARMACEUTICALS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Our goal is to develop a new molecular entity with a novel mechanism of action for targeting and eliminating glioblastoma multiforme (GBM, high grade glioma), a deadly and invasive brain tumor with no effective treatment. Of the 12,000 patients expected to be diagnosed with GBM this year, most will succumb within a year. There is an urgent demand for an efficac ...

    SBIR Phase II 2013 Department of Health and Human Services
  10. SapC-DOPS Nanovesicles for Treating Glioblastoma Multiforme

    SBC: BEXION PHARMACEUTICALS, INC.            Topic: 102

    DESCRIPTION provided by applicant Our goal is to develop a new molecular entity with a novel mechanism of action for targeting and eliminating glioblastoma multiforme GBM high grade glioma a deadly and invasive brain tumor with no effective treatment Of the patients expected to be diagnosed with GBM this year most will succumb within a year There is an urgent demand for an efficac ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health

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