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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. STIMULUS PAIRS IN 3D AUDITORY BRAINSTEM RESPONSE

    SBC: ABRATECH CORPORATION            Topic: N/A

    THE GOAL OF THIS RESEARCH IS TO DETERMINE THE FEASIBILITY OF COMBINING THREE-CHANNEL RECORDING OF THE AUDITORY BRAINSTEM RESPONSE (ABR) WITH A STIMULUS-PAIRS TECHNIQUE SO AS TO MEASURE THE DECREMENT IN RESPONSE THAT OCCURS IN THE RELATIVE REFRACTORY PERIOD (RRP). THIS METHOD WILL PERMIT DETECTION OF ANY ABNORMALITIES THAT AFFECT THE RRP, AS THE PARAMETERS CAN BE ADJUSTED SO THAT THERE IS DECREMENT ...

    SBIR Phase I 1987 Department of Health and Human Services
  2. MEASUREMENT OF INTERLEUKIN-2 AND INTERLEUKIN-2 RECEPTOR BY ELISA

    SBC: Advanced Allergy Res Ctrs Inc            Topic: N/A

    DURING THE PAST 20 YEARS, DIFFERENT BIOLOGICAL ACTIVITIES HAVE BEEN DESCRIBED FOR LYMPHOKINES PRODUCED BY ACTIVATED LEUKOCYTES. INTERLEUKIN-1 (IL-1) IS A FACTOR PRODUCED BY ACTIVATED MONONUCLEAR PHAGOCYTES AND IS ESSENTIAL FOR SUPPORTING BOTH T-CELL AND B-CELL RESPONSES. ACTIVATED T CELLS PRODUCE INTERLEUKIN-2 (IL-2), A FACTOR NECESSARY FOR T-CELL PROLIFERATION. THIS SOLUBLE FACTOR EXERTS ITS BIOL ...

    SBIR Phase I 1987 Department of Health and Human Services
  3. TUMOR NECROSIS FACTOR (TNF) IS A 17,000-DALTON POLYPEPTIDE SECRETED BY MACROPHAGES WHICH HAS ANTITUMOR CYTOLYTIC ACTIVITY.

    SBC: A Woman's Health Concern            Topic: N/A

    TUMOR NECROSIS FACTOR (TNF) IS A 17,000-DALTON POLYPEPTIDE SECRETED BY MACROPHAGES WHICH HAS ANTITUMOR CYTOLYTIC ACTIVITY. TNF DOES NOT APPEAR TO AFFECT NORMAL CELLS AND HAS BEEN SHOWN REPEATEDLY TO EITHER KILL OR PREVENT THE GROWTH OF TUMOR CELLS IN BOTH IN VITRO AND IN VIVO MODEL SYSTEMS. TNF IS THOUGHT TO EXERT ITS EFFECT THROUGH A PROCESS INITIATED BY THE BINDING OF TNF TO SPECIFIC CELL SURFAC ...

    SBIR Phase I 1985 Department of Health and Human Services
  4. INCREASING THE THERAPEUTIC EFFICACY OF MANY ANTICANCER DRUGS.

    SBC: A Woman's Health Concern            Topic: N/A

    INCREASING THE THERAPEUTIC EFFICACY OF MANY ANTICANCER DRUGS.THE LONG-RANGE GOAL OF THIS PROPOSAL IS TO DEVELOP AN IN VITRO TEST TO IMPROVE SELECTIONS OF THERAPIES FOR INDIVIDUAL BREAST CANCER PATIENTS BY PREDICTING RESPONSE TO METHOTREXATE. EXISTING ASSAYS FOR BREAST CANCER CELLS CANNOT DETERMINE METHOTREXATE SENSITIVITY BECAUSE OF REQUIREMENTS FOR FEEDER LAYERS AND MEDIUM COMPONENTS WHICH CAN RE ...

    SBIR Phase I 1985 Department of Health and Human Services
  5. ASSAY FOR PREDICTING METHOTREXATE SENSITIVITY IN HUMAN BREAST CANCER

    SBC: Aeron Biotechnology, Inc.            Topic: N/A

    THE LONG-RANGE GOAL OF THIS PROPOSAL IS TO DEVELOP AN IN VITRO TEST TO IMPROVE SELECTION OF THERAPIES FOR INDIVD- UAL BREAST CANCER PATIENTS BY PREDICTING RESPONSE TO METHO- TREXATE. EXISTING ASSAYS FOR BREAST CANCER CELLS CANNOT DE-TERMINE METHOTREXATE SENSITIVITY BECAUSE OF REQUIREMENTS FORFOR FEEDER LAYERS AND MEDIUM COMPONENTS THAT CAN RESCUE SEN-SITIVE CELLS. THIS PROPOSA WILL,THEREFORE, EVAL ...

    SBIR Phase II 1987 Department of Health and Human Services
  6. ASSAY FOR PREDICTING METHOTREXATE SENSITIVITY IN HUMAN BREAST CANCER

    SBC: Aeron Biotechnology, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1985 Department of Health and Human Services
  7. IMMUNOLOGICAL AND DNA HYBRIDIZATION ASSAYS WHICH EMPLOY SPECIFIC ANTIBODY AND DNA PROBES ARE PROVING TO BE VERY VALUABLE IN THE IDENTIFICATION OF PATHOGENS AND IN THE DIAGNOSIS OF GENETIC DISEASES.

    SBC: Agouron Pharmaceuticals Inc.            Topic: N/A

    IMMUNOLOGICAL AND DNA HYBRIDIZATION ASSAYS WHICH EMPLOY SPECIFIC ANTIBODY AND DNA PROBES ARE PROVING TO BE VERY VALUABLE IN THE IDENTIFICATION OF PATHOGENS AND IN THE DIAGNOSIS OF GENETIC DISEASES. THE OBJECTIVE OF THIS PROJECT IS TO IMPROVE THE SENSITIVITY, SAFETY, AND CONVENIENCE OF DIAGNOSTIC TESTS BY DEVELOPING A NONRADIOACTIVE, LUCIFERASE BASED PROBE TECHNIQUE. TO EVALUATE THE USEFULNESS OF L ...

    SBIR Phase I 1985 Department of Health and Human Services
  8. DEVELOPMENT OF DIAGNOSTIC PROBES FOR AUTOIMMUNE DISEASE

    SBC: Agouron Pharmaceuticals Inc.            Topic: N/A

    N/A

    SBIR Phase I 1985 Department of Health and Human Services
  9. THE PURPOSE OF THE RESEARCH IS TO DEVELOP A TOTAL TRANSPORTATION SYSTEM DESIGNED TO MEET THE COMMUTING NEEDS OF THE ELDERLY AND HANDICAPPED.

    SBC: Air Care, Inc.            Topic: N/A

    THE PURPOSE OF THE RESEARCH IS TO DEVELOP A TOTAL TRANSPORTATION SYSTEM DESIGNED TO MEET THE COMMUTING NEEDS OF THE ELDERLY AND HANDICAPPED. IT WILL COMBINE PRE-EXISTING GROUND PARATRANSPORTATION WITH AN AIR COMMUTER THAT IS MEDICALLY SUPPORTED. THE PROPOSED SYSTEM WILL PROVIDE GROUND TRANSPORTATION FROM THE RESIDENT'S DOOR TO THE AIRCRAFT DOOR. THEN THE PASSENGERS ARE AIDED ON BOARD THE AIRCRAFT, ...

    SBIR Phase I 1985 Department of Health and Human Services
  10. CARRAGEENAN-STABILIZED COLLOIDAL GOLD BIOSENSOR ELECTRODES

    SBC: ALDERON BIOSCIENCES, INC.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services

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