Award Data

Galois is creating an innovative systems software engineering framework that allows DoD, OEMs, and commercial customers the ability to decompose existing software systems into discrete components, incorporate new capabilities and cyber security modifications, and then recompose the software with new software modules. The result will be a workflow engine tool that enables organizations to reuse and ...

PROJECT SUMMARY The goal of this project is to complete the preclinical development of Elex Biotechandapos;s novel compounds that target and treat the underlying molecular cause of catecholaminergic polymorphic ventricular tachycardia (CPVT) CPVT. There are no FDA-approved treatments for CPVT, a rare genetic disorder affecting 1/10,000 individuals, with typical onset in children 7-9 years of age a ...

This application describes the commercialization of the Geodesic Transcranial Electrical Neuromodulation (GTEN) technology to achieve noninvasive neuromodulation with improved spatiotemporal precision. The GTEN system enables both EEG source analysis and configurable electrical neuromodulation with the 256 electrodes of the Geodesic Sensor Net. Now in beta release to selected research customers, t ...

Abstract Adolescents in the juvenile justice system demonstrate very high rates of tobacco, alcohol, and other drug use (ATOD), with rates that are estimated to be three times higher than non-justice-involved youth. Substance- abusing youth – especially those who are involved in the juvenile justice system – are at higher risk than nonusers for mental health problems, including depression, con ...

PROJECT SUMMARY Sickle Cell Disease (SCD) affects 100,000 Americans and more than 14 million people globally, primarily in economically disadvantaged populations. It is estimated that nearly 50-90% of children born with SCD in these areas die before the age of five, although 70% could be saved through simple, cost-effective treatments if diagnosed early according to World Health Organization. Earl ...

Abstract Deviant peer affiliation is one of the most important predictors of alcohol use in adolescence. These affiliations often arise when socially marginalized youth self-aggregate and reinforce alcohol use and other deviant activity (i.e., “deviant peer clustering”). Even though the field has developed efficacious school-based prevention programs, program effects are generally small, and t ...

ABSTRACTThe proposed intervention, Culturally Responsible Stress Reduction: A Mobile Mindfulness Application to Support Health Promotion for African Americans (CRSR), is designed to encourage the use of mindfulness to mitigate the disproportionate amount of stress-related health disparities facing African Americans. Current mindfulness approaches have been unsuccessful in engaging this population. ...

Abstract CylerusIncis developing an implantablesirolimus eluting cuff and reservoir systemcombined with a clinically approved drug pumpto solve the difficult problem of prosthetic vascular graft failureVascular grafts constructed using either synthetic polymers or native veins are widely used in vascular surgeryThe most common indications for these grafts areHemodialysis accessin which blood acces ...

This Phase II Small Business Innovation Research project develops the scale of lithium-ion direct recycling technologies applied to gain efficiencies in materials management from original manufacturing to end-of-life. The scrap materials are from Defense Logistics Agency manufacturing activities. A successful effort moves direct recycle TRL from 4 to 6, increases process throughput, qualifies mate ...

Project Summary Although potent antithrombotic drugs are availableall inadvertently target vital hemostatic mechanismsresulting in dose limiting hemorrhagic toxicity that restricts their useDue to a lack of safe thromboprophylaxisthrombotic thromboembolic blood vessel occlusions and vascular device failures remain among the leading causes of death and severe chronic disability in the U SConsequent ...