Award Data

In this proposal, we describe spatially resolved acoustic spectroscopy (SRAS), a relatively new and low TRL technology capable of conducting large-scale orientation microscopy. In its current form, it is capable of analyzing local crystal orientation on polished metallic surfaces, and is an a viable candidate to permit the nondestructive and non contact characterization of certain aspects of the m ...

ABSTRACTHeart disease is the leading cause of death in the United StatesCoronary heart diseaseCHDis the most common type of heart diseaseEvery yearmillions of Americans suffer otherwise preventable cardiac events resulting indeaths and $billion dollars of economic damage each yearThe prevalence of CHD varies by ethnicityNeverthelessfortunatelyCHD related morbidity and mortality can be prevented th ...

Project Summary Abstract TypediabetesT Dis characterized by both a loss of insulin sensitivity of target tissuesfatskeletal muscleliverand ultimatelyimpaired insulin secretion from the pancreaticcellWe have identified a novel SWELLmediated signaling pathway that regulates both insulin sensitivity and insulin secretionwhereby SWELLloss of function can both negatively regulate insulin signaling in t ...

The diseases caused by dengue virusesDENVmosquito borne members of the family Flaviviridaehave emerged as the most important arthropod borne viral diseases of humansThe frequencygeographical distributionand severity of DENV epidemics have increased dramatically over the past decadeDENV is spread by mosquito species that also harbor Zika virusZIKVand yellow fever virusAlthough these viruses are end ...

Problem: U.S. swine herd reproductive performance is limited more by sire subfertility than dam. Today’s boar semen processing and handling techniques have been largely unchanged since the 1980s. The newly identified, but long-­‐time existing technical problem is that current techniques promote non-­‐desired biological events during storage that shorten the in vivo lifespan, deem a conside ...

he proposal addresses development of an innovative one-pass drying technology that uses 915MHz microwave heating characteristics to maximize head rice yield (HRY) recovery. Head rice-- which is the mass of milled rice kernels that are at least three-fourths of the original kernel lengthafter milling of brown rice--is the high-value portion of processed/dried rice. National revenuelosses related to ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to develop a resonant sensor system to monitor cell viability in small bioreactors. Cell factories are responsible for producing more than $150B worth of cell therapies, protein therapies, industrial enzymes, and small molecules each year. At the development phase, there are few technologie ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I Project is to provide the pharmaceutical industry with improved pre-clinical screening assay for oral drug absorption. Current in vitro methods for characterizing gastrointestinal absorption are based on unreliable assays, with 90% of all drugs developed ultimately failing to enter the market. Practic ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project is to develop technology to address a significant pain point for farmers associated with reducing nitrogen fertilizer input costs. The technology is based on in-planta sensor technology that will allow farmers to more carefully and precisely tailor nitrogen applications to each part of each field. By ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will result from a significant reduction in traffic delays, crashes, and fatalities by implementing a fully adaptive traffic signal re-timing solution. The most recent National Traffic Signal Report Card gave a failing grade of D+ to traffic signal operations in the United States. These failin ...