Award Data

Project Summary Abstract Overspinal fusions are performed annually in the US of whichundergo revision due to failure to fuseThe mean age for spinal fusion increased fromtoyears inIn patients older thanyearsthe frequency of osteoporosis is reported to bein women andin manThese patients experience substantial deterioration in the quality of lifeincreased dependency on othersand reduced lifespanVerte ...

! Project Summary Millions of Americans today have an opioid use disorderOUDMillions more misuse opioidsand the crisis continues to growThe goal of this proposal is to speed the discovery of non addictive analgesics by providing drug discovery teams with simplermore robustmore quantitativeassays for agonist biasDriven by the urgency of the problem we are seeking Fast Track support to create new as ...

Summary Abstract There are currently no tools available that can objectively measure painHistoricallypain in humans has been measured using subjective ratings to determine presence and severityIn animal modelspain is measured by semi quantitative assays that rely on the observation of pain behaviorsThough usefulthe inherently subjective nature of these measures has hampered both research and treat ...

PROJECT SUMMARY In the United Statesaortic aneurysmal disease ranks among the topleading causes of deathPatients with aortic aneurysmsAAsare typically asymptomatic until dissection and then symptoms resemble other ailmentswhich can delay a correct diagnosisMortality associated with aortic dissectionADis high and rapid due to rupture of the aortaReducing mortality from aneurysmal disease requires i ...

The Air Force requires a system to provide over the horizon tracking to support development and test of Sea Skimming Missiles (SSM). Under this SBIR Phase I effort, Defense Research Associates, Inc.(DRA) will document system requirements, identify and assess sensor technologies capable of performing the missile tracking task, develop a system design to meet the requirements using the most promisin ...

In the naval aircraft many disparate materials are subject to galvanic corrosion, due to the marine environment. Some of these aircraft have hybrid (carbon fiber composite/aluminum) designs that exhibit accelerated corrosion damage, compared to legacy all-metal frames, due to galvanic interaction between the fastener, the composite skin, and the aluminum frame. In the Phase I SBIR program, UES Inc ...

Summary AbstractYouth under ageinvolved in the criminal justice system are disproportionately minorities and affected by substance abusemental illnessand HIV STIMost young offenders are released on community supervision without the STImental healthor substance use screeningdiagnosisand treatment afforded detained youthdespite similar rates of risk behaviorTheir long term trajectory is poorthe cost ...

SUMMARY Despite significant advances in the surgical and medical management of congenital heart diseasecongenital cardiac anomalies remain a leading cause of death in the newborn periodMost severe forms of congenital heart disease require multiplestaged surgical interventionsA significant source of the heightened morbidity and mortality associated with these operations is the development of cardia ...

NIH SBIR PA-18-871 w/o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System The intriguing human brain is the most imaged end-organ non-invasively, without ionizing radiation using magnetic resonance imaging (MRI). High spatial resolution brain MRI is an established diagnostic tool to assess injury mechanisms affecting newborn growth and the adult human connectome. To predic ...

The importance of determining crystallographic orientation information over large areas has existed within the materials science community for solutions to a variety of applications in aerospace and otherwise since the connection of MTRs and material performance was discovered, but it isn’t until recently that a feasible solution has existed. In this work, MRL will demonstrate the feasibility of ...