Award Data

ABSTRACT The detection of chromosomal aberrations is a frontline diagnostic for the spectrum of blood neoplasms. Chromosomal aberrations, such as translocations, inversions, deletions and insertions, have been historically identified using cytogenetic methods or more recently through application of long read sequencing or optical mapping technologies. These methods have been less applicable in sol ...

The broader impact of this Small Business Innovation Research (SBIR) Phase II project includes enhancing US economic competitiveness, improving the health and welfare of the American public, and developing the US technical workforce. The success of this project will have a direct impact on the manufacturers, integrators, and operators of battery-powered assets. Empowering battery engineering teams ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to develop a core enabling technology for lunar in situ resource utilization: the ability to sort “Moon dirt” (lunar regolith) by particle size. Size sorting is an important capability for nearly all in situ resource utilization activities that use lunar regolith as a feedstock material ...

Project SummaryWe propose developing and validating a novel platform technology that combines the collection and chemical analysis of ultrafine particles using an in-situ multispectral technique. The sample, collected directly onto the analysis substrate, is analyzed via excitation-emission matrix (EEM) spectroscopy. This approach will be validated against laboratory combustion-generated aerosols, ...

PROJECT SUMMARY The Apto-Ankle project will create a novel low-cost, lightweight, unpowered passive compliant ankle that addresses the weaknesses of currently marketed hydraulic passive ankles by combining +/-10° of plantar and dorsiflexion with a gait dependent toe lock to provide energy storage and return, all without use of microprocessors or powered components. Appropriate for DMERC K-2 and K ...

PROJECT SUMMARY Rheumatoid arthritis (RA) is a prevalent autoimmune disease of the joints that involves autoimmunity, B and T cell infiltration, mitochondrial dysfunction, ECM degradation, oxidative stress and inflammation, that ultimately lead to cartilage destruction and bone reabsorption. Oxidative stress is a hallmark of RA: reactive oxygen species (ROS) inflict direct damage via the oxidation ...

ABSTRACT The COVID-19 pandemic caused by SARS-CoV-2 viruses has had an unprecedented disruptive global impact. Although vaccination has been expected to end the spread, the fast mutations have increased the breakthrough infection rates in the fully vaccinated population. RNA viruses are known to have very high rates of mutation and evolution. The high rate of mutation is correlated with virulence ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is to create a rocket engine manufacturing business that would supply off-the-shelf, inexpensive, and reusable engines for current and future civilian and military rocket builders that want to launch small payloads to space.There are currently only two established companies that offer large e ...

The broader impact/commercial potential of this Phase I Small Business Innovation Research (SBIR) project is to develop a small plasma confinement device called an orbitron, which could have applications to allow low cost, highly mobile fusion sources. Markets with the largest opportunity to benefit from small, carbon-free, micro-fusion reactors are the “hard-to-decarbonize” industries like lo ...

Per- and polyfluoroalkyl substances (PFAS) have been used extensively for DoD firefighting applications due to their thermochemical stability and unique properties. PFAS are long-lived in the environment and coming under increased regulatory scrutiny due