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SBC: NANOSD, INC. Topic: DEFOA0001429
NanoSD, Inc. with its partners will develop a transparent, nanostructured thermally insulating film that can be applied to existing single-pane windows to reduce heat loss. To produce the nanostructured film, the team will create hollow ceramic or polymer nanobubbles and consolidate them into a dense lattice structure using heat and compression. Because it is mostly air, the resulting nanobubble s ...STTR Phase II 2016 Department of EnergyARPA-E
SBC: SOLUBLE THERAPEUTICS, INC Topic: 100
DESCRIPTION provided by applicant The increasing output of new integral membrane protein IMP structures is partially due to the availability of an increasing number of chemical variables such as detergents detergent like molecules lipids and solubilizing stabilizing additives It is clear that specific combinations and concentrations of these different variables are often necessary to impr ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: ADEPTHERA, LLC Topic: NICHD
DESCRIPTION provided by applicant Preeclampsia is a pregnancy specific hypertensive disorder that can lead to multi organ failure seizure and maternal death Preeclampsia is also responsible for as many as of premature births in the United States Although better neonatal care has improved the likelihood of preterm babies surviving many face increased mortality and serious long term mor ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: Prosolia, Inc. Topic: NIGMS
DESCRIPTION provided by applicant Most samples of chemical interest are complex mixtures making the usual combination of chromatography with mass spectrometry MS a natural choice However the increased demand for chemical analysis by mass spectrometry in many areas of science makes it imperative to increase efficiency of analysis by minimizing sample workup and overall analysis time which ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: DNATREK, LLC Topic: NIEHS
DESCRIPTION provided by applicant Science based strategies for quantifying and mitigating the impact of anthropogenic emissions on public health are essential for the sustainability of cities Similar strategies can also be used to develop and assess the effectiveness of a national defense system against terrorist attacks with airborne biological agents and protect against the spread of airborn ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: MAVERIX BIOMICS, INC. Topic: NIDA
DESCRIPTION provided by applicant The broad objective of this project is to develop an integrated wet lab dry lab kit for high throughput detection of RNA modifications The final product will provide all required molecular biology reagents a set of simple and robust experimental manipulations for facile analysis of modifications and researcher friendly analytic cloud based software requi ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: Anteana Therapeutics Inc Topic: NIDDK
DESCRIPTION provided by applicant Non steroidal anti inflammatory drugs NSAIDs are among the most widely consumed pharmaceuticals but their prolonged use causes gastric injury and damage to the small intestine Previous work has shown that anandamide an endogenous endocannabinoid substance produced in the gastrointestinal GI mucosa plays an important role in epithelial homeostasis and re ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: SignalRx Pharmaceuticals Inc. Topic: 102
DESCRIPTION provided by applicant There is an unmet need to inhibit the key cancer promoting transcription factor MYC MYC both cMYC and MYCN acts downstream of many cell receptor complexes and signal transduction pathways to activate genes that drive cancer cell growth and proliferation To date small molecule inhibitors of MYC have been elusive An innovative approach would be to indirectl ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: TRELLIS BIOSCIENCE, INC. Topic: NIAID
DESCRIPTION provided by applicant About of serious bacterial infections are biofilm mediated Not only do biofilms provide an anchor and physical protection for bacterial cells but the physiology and genetic programming of bacteria also shifts between the planktonic free floating and sessile stationary states Most notably antibiotic sensitivity differs betwen the two states with ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: KWJ ENGINEERING INC Topic: NIEHS
DESCRIPTION provided by applicant The goal of this STTR Phase I collaboration between KWJ Engineering KWJ and North Carolina State University NCSU will be development of a unique autonomously powered wearable environmental gas sensor for personal exposure monitoring PEM The approach will be to integrate KWJ ultralow power high performance printed amperometric gas sensor for key atmosp ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health