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SBC: BIOLOGICAL ANTI-INFECTIVE MEDICINES, LLC Topic: NIAID
DESCRIPTIONprovided by applicantNational surveillance data confirm thatof Abaumannii isolates from US intensive care units are extreme drug resistanceXDRfar higher than other pathogensAt leastandcases of XDR Abaumannii infections occur annually in the US and globallyin developed countriesrespectivelyThese infections result inanddeaths and excess healthcare costs of $million and $million in the US ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: SILVER LAKE RESEARCH CORPORATION Topic: NIAID
PROJECT SUMMARY ABSTRACT This proposal describes Phase II of the development of a rapid immunoassay test kit for the determination oflactam antibiotic resistanceto be used as a point of care diagnostic test for urinary tract infectionsTodayantibiotics for UTI are prescribed empiricallywith no diagnostics available to clinicians to avoid treating resistant infections with the very drug to which the ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: NeuroSigma, Inc. Topic: 101
DESCRIPTIONprovided by applicantThe purpose of this project is to develop an improvedminimally invasive treatment for intracranial aneurysmsIntracranial aneurysms are spherical outpouchings of blood vessels in the head that result from weakness in the vessel wallUnruptured aneurysms are present in approximatelyof the general populationand rupture can be devastating with a high morbidity and mortal ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: SYMBIOTIX BIOTHERAPIES, INC. Topic: NIAID
DESCRIPTION provided by applicant Multiple sclerosis MS is a chronic demyelinating inflammatory disease that is the most common neurological disease of young adults affecting over patients in the US and over million patients worldwide MS is a disease of high unmet medical need currently treatable with one of twelve FDA approved drugs all of which result in either significant i ...STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: Cyteir Therapeutics, Inc. Topic: NCI
DESCRIPTION provided by applicant Genomic instability is a hallmark of cancer and represents a targetable vulnerability yet is underdeveloped as a therapeutic area The central goal of this Phase program is to complete the early preclinical development of a new class of new cancer therapeutics that uniquely target RAD delivering effective cancer cell selective therapy in subsets of bioma ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: WinSanTor, Inc. Topic: NCI
PROJECT SUMMARY Chemotherapy induced peripheral neuropathyCIPNis a debilitating condition that afflictsof cancer patients undergoing chemotherapy and limits the dose and duration of treatmentSymptoms range from sensory loss to painful neuropathy and are accompanied by electrophysiological and structural indices of nerve damageThe American Society of Clinical Oncology currently makes no recommendat ...STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Xona Microfluidics, Inc. Topic: 101
DESCRIPTIONprovided by applicantNeuron cell culture is widely used for studies in basic researchdrug discoveryand toxicity testingTraditional neuron cell culture approaches result in random growth of processes which prevent the study of their unique polarized morphologyOur goal is to provide robustuser friendlyand cost effective culture platforms to manipulate and access neurons and their subcellu ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: SYMBIOTIX BIOTHERAPIES, INC. Topic: 300
PROJECT SUMMARY ABSTRACT Interactions between the gut microbiome and the immune system have been linked to inflammatory bowel disease IBD IBD is a chronic and progressive gastrointestinal disease characterized by uncontrolled activation of the intestinal immune system resulting in severe medical complications affecting over million patients in the United States It is a disease of high u ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: SIGMOVIR BIOSYSTEMS INC Topic: NIAID
DESCRIPTION provided by applicant Respiratory syncytial virus RSV is a substantial threat to human health most severely affecting three large populations infants young children and the elderly Despite the significance of RSV disease in these different populations there are no vaccines available The goal of this Phase II STTR project is to continue preclinical testing of a novel RSV vac ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: PROFUSA, INC. Topic: NHLBI
DESCRIPTION provided by applicant Continuous biochemical monitoring has the power to change currently accepted standards of care shifting the emphasis from treating illness to maintaining health Point in time snapshots of a patientandapos s health can miss critical fluctuations or early warning signs that might warrant early interventions or changes in disease treatment and management PROFUS ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health