Award Data

Through this STTR contract, we propose to evaluate the efficacy of our vaccine, FlowVax Marburg, in nonhuman primates (NHPs). This will be achieved through four Tasks. In Task 1, we will manufacture the vaccine in a quantity sufficient for the animal studies. In Task 2, we will perform MHC genotyping on a representative population of NHPs and, based on results, select a set of MHC-matched NHPs for ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terrible morbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditional vaccines have contributed greatly to public health, they have some limitations especially in the context of operati ...

ATA Engineering has developed a wavelet-based damage squeezing methodology for generating optimally compressed fatigue test signals that produce an equivalent amount of fatigue damage in a predictably reduced amount of time compared to the baseline (uncompressed) signals. Fatigue-critical signal characteristics (e.g., magnitude, phase, frequency, and sequencing relationships) are identified in the ...

Additive manufacturing (AM) bring revolutionary capabilities and is very attractive to various commercial and military applications. However, metal AM often results in components with various defects, which may have decisive impact on their mechanical properties. To address this critical concern of AM quality, in this research, Intelligent Automation, Inc (IAI) will develop and implement a materia ...

Materials for thermal protection are required to protect structural components of missile launching systems, space vehicles during the re-entry stage, and solid rocket motors (SRMs). Polymer resins that have high char retention (e.g., phenolic resins) are the most common matrices in the composite materials for rigid thermal protection systems (TPSs) due to their tunable density, lower cost, and hi ...

The objective of this project is to advance the capabilities of the Coastal Battlefield Reconnaissance and Analysis (COBRA) system by creating a Surf Zone Modelling Tool (SZT) that can create realistic synthetic imagery of the surf zone (SZ). Through the use of this synthetic imagery the COBRA Program will be enabled to inform concept of operations (CONOPS) in unfamiliar environments as well as mo ...

Active imaging systems are used in degraded visual environments, like those found in marine fog and other areas with a high level of attenuation and scattering from obscurants like rain, smoke and dust. These systems are still limited in range and resolution. SA Photonics is taking advantage of new eyesafe, hybrid fiber-bulk laser technology capable of high pulse energy at high repetition rate to ...

Current design tools for gas turbine engines invoke a variety of simplifying assumptions to estimate heat transfer to solid/metal engine components (e.g., isothermal boundary conditions). These approximations are often not valid, result in inaccurate predictions of heat transfer, and ultimately compromise the thermal integrity of propulsion and power systems. Wall-modeled large eddy simulation (WM ...

During Phase I and Phase II, M4 Engineering, Inc. and Sandia National Laboratories have created a unique bonded joint analysis methodology and associated software. During Phase II.5, the developed techniques will be further enhanced and a fully functional commercial analysis code (SIMULIA/Abaqus) plug-in will be created. The software plug-in will make the advanced technology accessible to all leve ...

We propose the design and development of LCS radar modeling for training a radar modeling engine that capture the effects of environment, weather, jamming/interference and operator actions on radar display. The purpose of this engine is to reduce or eliminate the need for live training by faithfully capturing the scenarios encountered by a radar operator. The primary target radars for the propose ...