Award Data

During altitude-induced hypoxia, operator cognitive and physical capacity degrades, compromising individual and team performance. Cognitive degradation is linked to falling brain energy levels, increased reliance on anaerobic energy production and lactate accumulation. Ketones are the evolutionary alternative substrate to glucose for brain metabolic requirements; previous studies demonstrated that ...

PROJECT SUMMARY ABSTRACT This proposal describes Phase II of the development of a rapid immunoassay test kit for the determination oflactam antibiotic resistanceto be used as a point of care diagnostic test for urinary tract infectionsTodayantibiotics for UTI are prescribed empiricallywith no diagnostics available to clinicians to avoid treating resistant infections with the very drug to which the ...

DESCRIPTIONprovided by applicantThe purpose of this project is to develop an improvedminimally invasive treatment for intracranial aneurysmsIntracranial aneurysms are spherical outpouchings of blood vessels in the head that result from weakness in the vessel wallUnruptured aneurysms are present in approximatelyof the general populationand rupture can be devastating with a high morbidity and mortal ...

Project Summary Occidiofungins (A-D) are cyclic nonribosomally synthesized antifungal peptides with submicromolar fungicidal activity against a broad spectrum of fungi. Optimization of the production and isolation of occidiofungins from liquid cultures has been performed. The production and isolation of predominantly one analog, called occidiofungin B (OCF001), supports its commercial development ...

DESCRIPTION (provided by applicant): In the past years, we have shown that human umbilical cord blood cells (HUCBC, U-CORD- CELL ) provide cognitive recovery in animal models of neurodegenerative disease. Infusion of HUCBC resulted in reduced infarct volume as well as in rescue of behavioral benefits in an animal model of stroke. We further showed that HUCBC infusion proved to be beneficial in ani ...

The objective of this project is to develop a comprehensive suite of tools, called the DAA Radar Software Suite and Simulation (DAA-RSSS), that supports future Navy procurement and certification of non-cooperative sensor technologies for Detect And Avoid (DAA) as well as develop plans to support EO/IR sensors as the non-cooperative sensor as informed by FAA activities in developing Minimum Operati ...

Glioblastoma (GBM) is the most lethal form of adult brain cancers with a median survival of andlt;15 months despite aggressive standard chemoradiation. GBM are formed by GBM stem-like cells (GSCs) - a major contributor to tumor recurrence and a natural focus for therapeutic development. There are two main reasons responsible for treatment failure: 1) high intra- and inter-tumor cellular and molecu ...

Active imaging systems are used in degraded visual environments, like those found in marine fog and other areas with a high level of attenuation and scattering from obscurants like rain, smoke and dust. These systems are still limited in range and resolution. SA Photonics is taking advantage of new eyesafe, hybrid fiber-bulk laser technology capable of high pulse energy at high repetition rate to ...

Additive manufacturing is a disruptive new manufacturing paradigm that hold tremendous potential for creation of novel designs and introduction of novel new alloy systems. However, much of this potential remains unrealized due to a lack of robust material properties databases. Accurate calibration of materials models and robust part qualification and certification regimes both will require massive ...

The Internet of Things (IoT) connects people, data, and "things" (e.g., software, sensors, platforms), facilitating the translation of information into actions. Although naval platforms’ networks and communication suites have evolved significantly in the past few years to support such required connectivity, one of the greatest technical challenges still facing the military community is the proce ...