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SBC: GLOBAL RESEARCH & DEVELOPMENT INC Topic: DHA17B005
This proposal is in response to the Defense Health Agency 2017 Phase I SBIR topic 17B-005.The approach is the use of a membrane oxygen pump using newly developed nano-thickness membranes with all the layers less than 1 micron total.Nanometer thickness membranes enable more oxygen output per surface area at temperatures of 300-600 C than current state-of-the -art 600-800 C membranes that are 50-300 ...STTR Phase I 2018 Department of DefenseDefense Health Agency
SBC: MICROELECTRONICS RESEARCH DEVELOPMENT CORPORATION Topic: DTRA16A003
Micro-RDC has developed portable radiation effects test structures that scale to new process nodes.These structures will enable the investigation of the effects of radiation on the new technology from the material processing level as well as the circuit level.Fabricating the chosen structures and the refinement of software to extract the model parameters will be completed in this effort.A suite of ...STTR Phase II 2018 Department of DefenseDefense Threat Reduction Agency
SBC: IMMUNOBLUE, LLC Topic: NCI
PROJECT SUMMARY Melanoma is one of the most prevalent cancers and is estimated to account for overdeaths inin the United States aloneAlthough highly curable when detected earlytheyear survival rates decline precipitously for patients with regionaland metastaticmelanoma indicating a lack of efficacy of conventional therapiesand a strong need for novel therapies for this patient populationIn respons ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Building an evidentiary case for circulating GHBP as a biomarker for drug-associated stunting of growthSBC: REVERAGEN BIOPHARMA, INC. Topic: NICHD
There is increasing interest in the use of biomarkers in clinical drug developmentwith much of thest Century Cures Act focused on encouraging this approachIdeallybiomarkers could provide and acute and objective read out of drug mechanism of actionpharmacodynamic biomarkersor prediction of later clinical benefit or harmsurrogate outcome measureHoweververy few biomarkers have been validated for rout ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Universal Adherence LLC Topic: N
Project Summary Abstract Universal Adherence is an emerging medical device company dedicated to improving adherence to ocular medications through innovative technical solutionsOur proposed Devers Drop DeviceDwill accurately track when a patient removes an eye drop bottle capcommunicate usage data wirelessly to a database that researchers can accessand send alerts to patients when a medication is d ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Noninvasive placement and activation of deep-brain stimulating magnetic particles for reduction of drug-seeking behaviorsSBC: WEINBERG MEDICAL PHYSICS, INC. Topic: NIDA
Abstract Deep brain stimulationDBSwith implantable electrodes has been used for reduction of ethanol abuse and drug seeking behaviors in EuropeThe use of such deep brain stimulation procedures has been problematic because of concerns about invasiveness of the procedureApplicant has developed a new noninvasive method of transporting magnetic particles directly to target sites within the brainWe pro ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Production and Characterization of Human Immunoglobulin Producing Goats for Diagnostic Reagents and TherapeuticsSBC: SAB CAPRA, LLC Topic: NIAID
Project Summary A research plan is proposed to engineer goats that produce fully human immunoglobulinThese animals will be evaluated as a candidate platform system for production of both targeted therapeutic immunoglobulin as well as reagent antibodies for standards and controls of serological assays of human clinical samplesPrevious studies have demonstrated that ungulates such as cattle can prod ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: AMELIA TECHNOLOGIES LLC Topic: NIEHS
Project SummaryThe objective of this supplementation request is to further our recent advances in the development of thewell Immuno CometChip assay results and build a prototypewell preformer giving the assay more utility and increasing commercial viabilitySTTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: PHOENIX PHARMALABS, INC. Topic: NIDA
Abstract Currentlyclinically used drug abuse medications exist for treatment of addiction to opiatesalcoholand nicotinebut not cocaineThe objective of the proposed project is to test the hypothesis that the partial kappa agonist PPLcan be effective as a pharmacotherapy for treatment of cocaine abuseBecause of chronic drug induced changes in the kappa opioid receptor systemkappa receptor directed c ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: CHEMOSEN3D INC Topic: NIAID
Project Summary Adoptive immunotherapy trials using genetically modified natural killerNKand T cells with redirected specificity against B cell malignancies have demonstrated therapeutic efficacyTwo early phase clinical trials have been initiated at The University of Texas MDAnderson Cancer Center to evaluate the safety and efficacy of adoptive transfer of autologous and allogeneic T cells express ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health