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The need for simple and practical instrumentation for rapid identification and detection of biological agents has been recognized as an important research area in sensor development. Specific antibody/antigen binding, in conjunction with evanescent wave excited fluorescence sensing, has been applied to the detection of toxins and chemical and biological warfare materials. However, there remains a ...

Recent cognitive research indicates that military teams operate effectively in high-stress, information-rich environments when they 1) share mental models of the battlefield situation and the team; 2) critique their situation model to develop clear goals for information retrieval; 3) effectively communicate information needs to others; and 4) anticipate and counteract information overload. We pro ...

Inappropriate trust of automation can lead to suboptimal performance, in which the respective capabilities of humans and computers are not effectively exploited. In some cases, over- or under-reliance can lead to catastrophe. The primary objectives of the proposed Phase I work are (1) to develop a systematic general framework for training users of decision aids, with particular attention to the ...

The overall objective of the proposed program is to develop an eyesafe high-resolution Doppler lidar edge-technique-based sensor capable of 3 m spatial resolution, 0.2 m/sec velocity precision, and adequate temporal resolution to permit remote measurement of low altitude atmospheric disturbances to range of 1-10 km. The objective is to develop a compact, low-weight, low-power, and low-cost sensor ...

The objective of this basic research is to design and develop a low-frequency, ultra-wide band (UWE) antenna. Such an antenna combined with a pulse-generating radar system would be capable of penetrating and detecting targets through foliage, ice, snow, and even earth. Development of appropriate radar systems is state-of-the-art except for the antenna, which requires a breakthrough in technology ...

Frog Embryo Teratogenesis Assay: Xenopus (FETAX) is a 96-h, whole-embryo bioassay designed to detect potential developmental toxicants. The primary goal of this research is to improve the predictability and increase the overall utility of FETAX as a screen for developmental toxicants that pose a hazard to human health. Since Xenopus laevis embryos lack mixed-fliriction oxidase metabolism (cytoch ...

Optimization of antibody affinity and specificity is of paramount importance to the military for the development of biological warfare agent receptors and vaccine components. Exhaustive saturation mutagenesis of the complete antigen binding site for such optimization must typically involve the construction and characterization of several hundred mutants. Using conventional mutagenesis, the expen ...