Award Data

DESCRIPTION (provided by applicant): The proposed effort is aimed at the development and evaluation of a wireless electronic location system for reporting the location of individuals with autism and other cognitive disabilities, who may wander or elope. This is a very vexing and routine problem for caregivers, and sometimes results in physical and emotional danger to the individuals who may wander ...

DESCRIPTION (provided by applicant): This Fast-Track SBIR proposal submitted by SoloHealth of Duluth, Georgia, requests grant funds to build and test a multifunction health-screening kiosk. Our current kiosk prototype, EyeSite, has demonstrated efficacy inreaching low income, high health disparity populations with over 109,000 uses in less than 9 months of testing. Our goal is to expand the offeri ...

DESCRIPTION (provided by applicant): The objective of this Fast Track Small Business Innovation Research application, submitted by KDH Research and Communication (KDHRC), is to develop and evaluate an online information clearinghouse to support community-based nonprofit organizations' (NPOs) use of promotores programs to provide health information to underserved Latinos. Promotores programs u ...

DESCRIPTION (provided by applicant): This application is to deliver high-performance, GPU-enabled computation and visualization software tools to neuroscientists. Today, there are an estimated 1.5 million life science MATLAB users, with a substantial portion of those using MATLAB to solve neuroscience-related problems. MATLAB users, especially those dealing with large neuroscience datasets, such a ...

DESCRIPTION (provided by applicant): Cerebral ischemia is a major cause of death and long-term disability, with high accompanying social and medical costs. Approximately 795,000 Americans suffer a stroke each year at an estimated annual cost of 73.7B (American Heart Association. Heart Disease and Stroke Statistics, 2010 Update). Substantial preclinical data support the use of NMDA receptor antago ...

DESCRIPTION (provided by applicant): The most-widely used vaccine for TB currently is BCG, a live avirulent variant of M. bovis that is given intradermally at birth. Along with the inherent safety and logistical problems associated with being injected, protective efficacy is generally poor and wanes by adolescence. BCG administration to an immunosuppressed individual also can disseminate and lead ...

DESCRIPTION (provided by applicant): O-glycosylation of serine and threonine of nuclear and cytoplasmic proteins by a single beta-N- acetyl-D-glucosamine moiety (O-GlcNAc) is a ubiquitous post-translational modification that is highly dynamic and fluctuates in response to cellular stimuli. O-GlcNAc often competes with protein phosphorylation, and these two modifications have extensive crosstalk in ...

DESCRIPTION (provided by applicant): Overweight and obesity are major health problems, affecting over two-thirds of US adults. Standard behavioral treatments (SBT), which are the gold standard for mild and moderate obesity, have been adapted forInternet delivery to facilitate dissemination, reduce cost, and overcome barriers to treatment. However, the weight losses obtained via Internet- ...

DESCRIPTION (provided by applicant): 10.3 million Bioprosthetic heart valves (BHV) have been implanted since 1980 in the United States alone, but the solution for a durable, non-calcifying bioprosthesis still eludes us. High rates of structural failures and rapid calcificationin BHVs, has veered a gradual shift towards the development of polymeric heart valves (PHV). Biocompatible polymers are exc ...

DESCRIPTION (provided by applicant): Abnormal urethral sphincter contractions can prevent bladder emptying and cause significant morbidity and reduction in quality of life after neurological disease or injury. Existing treatment options are of limited effectiveness, destructive, or possess systemic side effects, reducing patient acceptance of these therapies. Electrical stimulation of sacral motor ...