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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. 2-HOBA for Treatment of Pulmonary Hypertension

    SBC: MTI Biotech Incorporated            Topic: NHLBI

    PROJECT SUMMARY Although the ubiquity of metabolic problems in pulmonary hypertension (PH) has been known for more than a decade, a wealth of new details on the nature of this problem presents the opportunity for intervention. A combination of experimental work in cells and animals and early trials in humans, suggests that these metabolic problems are part of the causation for PH, and that inactiv ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. An Improved Epigenetic Algorithm for Guiding Low Dose CT Lung Cancer Screening

    SBC: BEHAVIORAL DIAGNOSTICS, INC.            Topic: NCI

    SPECIFIC AIMSApproximately 90% of lung cancer results from smoking. Low Dose Computerized Tomography (LDCT) of smokers can detect lung cancer earlier allowing more effective treatment. But determining which smokers should get LDCT screening is controversial and potentially harmful. Recently, the U.S Preventive Services Task Force (USPSTF) updated their opinion on screening to recommend annual LDCT ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. A Virtual Project-Based Learning Sandbox for Mimetics and Medically Inspired Classroom Engineering (MiMICRE)

    SBC: PARAMETRIC STUDIO, INC.            Topic: 500

    Project Summary/Abstract: The U.S. has more health science STEM jobs available than qualified workers to fill them and lags other OECD nations in math and science, with major achievement gaps and STEM workforce under-representation among women and students of color. Improved STEM education is needed in high school and early collegiate settings that engages, prepares, and inspires all students—an ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Image-guided dosimetry-based alpha particle therapy for neuroblastoma.

    SBC: VIEWPOINT MOLECULAR TARGETING, INC.            Topic: 105

    SIGNIFICANCE: Neuroblastoma is the most common pediatric cancer, accounting for 15% of cancer deaths, with a 5-yr survival of lt40% due to resistant metastases. Neuroblastoma tumors almost universally express the somatostatin receptor 2 (SSTR2) and high expression has been shown clinically using peptides targeting SSTR2 (PMID10706954). FDA approved SSTR2-targeted beta(β-)-emitting 177Lu-labeled L ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Combining receptor-targeted alpha particle therapy and immunotherapy to achieve complete responses in metastatic melanoma

    SBC: VIEWPOINT MOLECULAR TARGETING, INC.            Topic: NCI

    Revised. Metastatic melanoma is a lethal disease because low response rates (near 50%), acquired resistance, and severe adverse side effects limit long-term quality of life for these patients (5-yr. survival lt30%). Radiopharmaceutical therapies are emerging as an exciting alternative in oncology and systemic receptor- targeted alpha-particle therapy (a-RT) is emerging as particularly transformati ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Ultrasound-based diagnostic and monitoring of bladder cancer treatment with drug released from nanoparticles

    SBC: NANOMEDTRIX LLC            Topic: NCI

    Project Summary/Abstract: Transitional cell carcinoma (TCC) of the bladder is the fifth most common form of cancer in the U.S., with over 80,000 new cases expected in 2019. For early-stage carcinomas, patients receive intravesical bacillus Calmette-Guerin (BCG) immunotherapy, or transurethral resection of the bladder tumor (TURBT) with intravesical chemotherapy. Both are associated with a high rat ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Discovery of Novel Pharmaceutical Agents for Skeletal Muscle Atrophy

    SBC: EMMYON, INC.            Topic: NIAMS

    PROJECT SUMMARY / ABSTRACT Skeletal muscle atrophy diminishes the health and quality of life of tens of millions of people in the US alone. Frequent causes of muscle atrophy (which often co-exist in the same patient) include aging, malnutrition, muscle disuse, critical illness, certain medications, and a broad range of chronic illnesses including cancer, heart failure, COPD, diabetes, renal failur ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Improving The Reproducibility and Genetic Stability of IPSC and Differentiated Cells Through Oncogene-Free Reprogramming and Fully Human Growth Factors

    SBC: Cellular Engineering Technologies, Inc.            Topic: 400

    Cellular Engineering Technologies (CET) has submitted this proposal in response to RFA-GM- 19-001. CET has proposed a direct Phase II SBIR application to create more reproducible human induced pluripotent stem cells (iPSCs) and create methods for growing, maintaining, and authenticating iPSCs. A major challenge in iPSC manufacturing and subsequent differentiation is the emergence of genetic instab ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  9. GMP peptide manufacturing, pharmacology/toxicology, and scaled radionuclide production and validation for Pb-212 receptor targeted alpha-particle therapy clinical trials for metastatic melanoma.

    SBC: VIEWPOINT MOLECULAR TARGETING, INC.            Topic: NCI

    Melanoma incidence in the United States is growing rapidly. Surgery combined with radiation can be curative at early stages but, metastatic melanoma is usually fatal. Since 2011, targeted MAPKi and immunotherapies have improved outcomes, but low response rates, acquired resistance, and adverse events limit quality of life for these patients (5-yr. survival andlt;25%). Under predicate Randamp;D, Vi ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a Micro-Mechanical Insertion Tool with Intraoperative Real-Time Electrophysiological Sensing Control for Cochlear Implantation

    SBC: iotaMotion, Inc.            Topic: NIDCD

    Project Summary/Abstract. One of the more recent goals of cochlear implant (CI) surgery is the preservation of residual hearing to improve overall patient outcomes. Unfortunately, up to 50% of patients experience delayed residual hearing loss following cochlear implant surgery, resulting in a diminished quality of life. To address this issue, iotaMotion is developing an insertion system to assist ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
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