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The problems this contract is addressing include making it easy for patients to report toxicities after radiation therapy so that they can be timely and accurate and so that they can be incorporated into a medical database for use by medical professionals. This would allow the app to recommend (when appropriate), and for clinicians to intervene, with appropriate treatments and will lead to better ...

Our company has invented a magnetic drug delivery device that we intend to develop to enable prevention of a major side effect of chemotherapy in children. Cisplatin and carboplatin chemotherapy regimens can lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. Hearing loss in kids has a dramatic impact on the ...

This research project seeks to create innovative software that aids cancer patient caregivers,by improving their ability to access patient information, communicate with clinicians, and provide peer support. We seek to leverage the insights of stakeholders and subject matter experts as well as industry standards to enhance a caregiver facing SmartPhone app and related software developed in Phase I ...

PROJECT SUMMARY Melanoma is one of the most prevalent cancers and is estimated to account for overdeaths inin the United States aloneAlthough highly curable when detected earlytheyear survival rates decline precipitously for patients with regionaland metastaticmelanoma indicating a lack of efficacy of conventional therapiesand a strong need for novel therapies for this patient populationIn respons ...

Project Summary The goal of this SBIR Fast Track project is to further the commercialization of PathoVax s bi valent RGVaxTM as a broad spectrum Human PapillomavirusHPVvaccine that targets all clinically relevant HPVsCurrent HPV vaccines provide type restricted protection that focuses only on sexually transmitted HPVs resulting in an unexpected STD stigma that directly affects uptake ratesBy targe ...

There is increasing interest in the use of biomarkers in clinical drug developmentwith much of thest Century Cures Act focused on encouraging this approachIdeallybiomarkers could provide and acute and objective read out of drug mechanism of actionpharmacodynamic biomarkersor prediction of later clinical benefit or harmsurrogate outcome measureHoweververy few biomarkers have been validated for rout ...

Abstract Respiratory syncytial virusRSVa viral agent that causes severe respiratory illnessinfects a large percentage of infants and children worldwide by the age of threeEHeylen et alAccording to the CDCRSV is responsible for overhospitalizations andmillion outpatient visits among children younger thanyears as well ashospitalizations anddeaths among the elderly in the US aloneEKMilleret alAfter m ...

Project SummaryOur long term objective is to commercialize a fastsimpleflexibleand economical system for affinity tag protein purification and tag removalThis technology was developed as a result of NIH funded studies on the foldingstability and enzymology of the Bacillus protease subtilisinThe transformative purification technology combines three componentsa regulatedhighly specific proteasePsubt ...

Abstract Deep brain stimulationDBSwith implantable electrodes has been used for reduction of ethanol abuse and drug seeking behaviors in EuropeThe use of such deep brain stimulation procedures has been problematic because of concerns about invasiveness of the procedureApplicant has developed a new noninvasive method of transporting magnetic particles directly to target sites within the brainWe pro ...

The overarching goal of this project is to develop a highly effective vaccine for prevention of Plasmodium falciparumPfmalaria based on a genetically attenuatedGAtriple gene knockout sporozoiteSPZstage parasite that is asepticpurified and safe for parenteral injectionIn this Phase I applicationwe propose to optimize the manufacturing processes for the vaccineSanariaPfSPZ GAand producelot suitable ...