Award Data

Future MDA space missions will utilize small spacecraft with correspondingly small, advanced sensor systems. Cooling of these sensors is required to decrease detector noise and increase detector sensitivity by maintaining the detector at a reduced operating temperature. The cooling system comprises a mechanical cryocooler and its control electronics, both of which are critical technologies to enab ...

Project SummaryAbstract The goal of this Phase I work is to finish development of an innovative interactive app designed to help patients appropriately use total knee replacementTKRsurgery and provide support to achieve best outcomesTKR is highly effective for treating advanced osteoarthritis of the kneebut it has risksAppropriate use can be assured by engaging patients in a Shared Decision Making ...

PROJECT SUMMARY ABSTRACTMillions of children around the globe are afflicted with conditions that can alter neuropsychological developmentincluding human immunodeficiency virusHIVtraumatic brain injuryTBIcerebral malariaand a host of other developmental and acquired diseases and disordersEarly assessment and intervention are critical in overcoming cognitive and developmental deficiencies and are in ...

PROJECT SUMMARY The filovirusesfamily Filoviridaecomprising five ebolavirusesa cuevavirusand two Marburg virusesare negative strand RNA viruses that cause severe hemorrhagic fever with up tohuman case fatality rateTheepidemic in Western Africacaused by the Zaire ebolavirusEBOVspecies demonstrated the potential for these viruses to cause dire health emergencies of global scopeand highlighted the ne ...

ImmuNext has defined an anti MCTmonoclonal antibodymAbthat will be developed for the treatment of human autoimmune diseaseThe membrane monocarboxylate nutrient transporter SLCAMCTis a multi pass transmembrane protein responsible for the facilitated transport of critical metabolitesincluding products of glycolysislactatepyruvate and ketonesOur strong preliminary data support the tenet that mAbs tha ...

PROJECT SUMMARYABSTRACT Older patients with persistent and progressive symptoms of chronic back pain and leg pain often have a diagnosis of lumbar degenerative spondyolisthesis and undergo complex lumbar decompression and fusion surgeryOverof these procedures are performed in the United States each yearSurgery is highly effective but technically challengingOne technical challenge of fusion in spon ...

PROJECT SUMMARY ABSTRACT Despite recent advances in the treatment of breast cancerBCthere is a pressing unmet medical need as BC remains the second leading cause of cancer related deaths among womenInnovative new approaches are especially needed to help patients with triple negative BCTNBCas TNBCandapos s inherently aggressive clinical behavior and the lack of recognized molecular targets for ther ...

AbstractPost operative pain is poorly managed and increases risk for delayed recoverychronic painopioid dependenceand persistent disabilityOne barrier to effective management of acute pain is the absence of objective measuresWe propose to conduct a feasibility study for technology to objectively measure postoperative painWe have selected back surgery as a model given its frequencycostand poor outc ...

Digital therapeutics are redefining the future of medicineDigital therapeutics refer to the use of mobile technology to provide personalizeddigital health interventions to treat diseasesThese tools enable anytime and anywhere healthcareGiven that there are more mobile phones in the world than there are people in the worlddigital therapeutics offer the potential to be transformativeThe applicant te ...

PROJECT SUMMARY ABSTRACT Clinical ImportanceAlmostmillion dental implants were placed worldwide inwithmillion of these procedures taking place in the United StatesThe worldwide market for these implants is expected to increase to $$billion in revenue byas more patients opt for this procedure to regain chewing function and improve cosmetic appearanceThe procedure itself requires an osteotomy be dri ...