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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 11 - 20 of 169241 results
  1. Development of the Movable Type free energy method for ligand placement in X ray crystallography

    SBC: QUANTUMBIO, INC.            Topic: 100

    Abstract The study of protein ligand binding is one of the central problems in computational biology because of its importance in understanding intermolecular interactions and because of its practical payoff in drug discovery efforts The transformative impact accurate target ligand structure can have in the design of next generation medicines cannot be overstated If we could routinely and accur ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. The Oaks A Mobile Exercise and Education Program for People with Osteoarthritis of the Knee

    SBC: BLUE MARBLE REHAB INC.            Topic: NIA

    Project Summary This Fast Track SBIR project long term objective is to develop and test of a minimum viable product MVP of The Oaks a perioperative digital education assessment and guided exercise software application for adults with osteoarthritis of the knee KOA awaiting total knee replacement TKR surgery This product is relevant to the mission of the NIA because it addresses the call ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Wound healing progress tracking through mobile devices

    SBC: Xyken, LLC            Topic: NIAMS

    Project Summary We propose in this SBIR effort to develop a smartphone or tablet based app for caregivers to perform non invasive and quantitative measurements of patientsandapos chronic wounds especially on diabtetic foot ulcers either at care facilities or at patientsandapos home Since chronic wounds take months or even longer to heal it is highly likely that more and more patients will be ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Development of live attenuated respiratory syncytial virus vaccines with novel thermal stable fusion protein

    SBC: Meissa Vaccines Inc            Topic: NIAID

    Respiratory syncytial virus RSV can cause lower respiratory illness LRI in otherwise healthy children and developing an effective prophylactic vaccine to mitigate RSV disease in infants is a public and global health priority according to the World Health Organization The overall goal of this project is to develop a safe and efficacious RSV vaccine for immunizing sero negative months to ye ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Inspiration Point A Digital Pulmonary Rehabilitation Tool for use with Self Management Interventions

    SBC: BLUE MARBLE REHAB INC.            Topic: NHLBI

    Project Summary The broad long term objective of this Fast Track proposal is to develop an innovative self management intervention SMI technology Inspiration Point for the treatment and study of Chronic Obstructive Pulmonary Disease COPD This application directly addresses the NHLBI SBIR requests for proposals for the development of innovative technologies for COPD the development of techn ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Development of Fibrin Specific Nuclear Probe to Reduce LVAD Adverse Events

    SBC: CAPELLA IMAGING, LLC            Topic: NHLBI

    Despite the myriad major advances in cardiology the prognosis for patients with severe medically refractive heart failure HF is exceedingly poor Approximately deaths occur annually in patients with HF who have endured an impaired quality of life often accompanied by significant economic and personal losses due to recurrent hospitalizations At least of these deaths were directl ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Noninvasive urinary monitoring of NASH by activity based nanosensors

    SBC: Glympse Bio, Inc.            Topic: 300

    Project Summary Abstract Nonalcoholic steatohepatitis NASH is dubbed the stealth epidemic and in the U S alone percent of the million people who are estimated to have NASH will progress and develop life threatening conditions including fibrosis cirrhosis hepatocellular carcinoma and liver failure By the year NASH is projected to be the leading indication for liver transplanta ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. MUC assay for the early diagnosis and management of benign and malignant pancreatic diseases

    SBC: Sanguine Diagnostics And Therapeutics, Inc.            Topic: 300

    Abstract The goal of this Fast track application is to develop a non invasive diagnostic test based on MUC and MUC mucins that can serve as an adjunct to cytological analysis of fine needle aspirates FNAs for accurate prediction of malignancy in patients with cystic pancreatic lesions Due to asymptomatic nature and lack of methods for early detection andgt of pancreatic cancer PC p ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Development and validation of a novel D human in vitro model of nonalcoholic steatohepatitis to be used for novel therapeutic screening and research on disease mechanism

    SBC: Organovo, Inc.            Topic: 365

    ABSTRACT Nonalcoholic fatty liver disease NAFLD is a chronic condition that originates as lipid accumulation within hepatocytes steatosis and progresses into nonalcoholic steatohepatitis NASH characterized by lipid accumulation inflammation oxidative stress and fibrosis An estimated million adults across the U S are thought to have NAFLD with up to million more estimated to hav ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. High Density Miniaturized Zero Switching Stimulation and Recording Headstage for Small Animals

    SBC: ADVANCED MEDICAL ELECTRONICS CORPORATION            Topic: 101

    Project Summary Abstract Combining high channel count electrophysiological recording of neural activity with patterned electrical micro stimulation has been severely constrained by technical limitations Foremost among these limitations are the problems associated with simultaneous recording and micro stimulation Stimulation artifacts are up to four orders of magnitude larger than the neural sig ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health

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