Award Data

Summary In a variety of diseases and conditions when oral feeding is impossibleenteral feeding through percutaneous gastrostomyPGis necessary to provide long term nutrition for adult and pediatric patientsIt is estimated that overthousand feeding tubes are placed in pediatric patients in the US annuallyHoweverthese patients frequently experience complications associated with PG tube placementLate ...

Summary Oral mucositisa severe oral ulcerationis a common toxic effect of radioor chemoradio therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatmentAt leastand up toof cancer patients treated with standard chemotherapy regimens or upper body radiation develop oral mucositisIntensity modulated RTIMRTlessens chronic side effectsbut not the acute toxicity s ...

AbstractThe exponential increase of diabetics and the elderly in the U Shas more than tripled the number of cataract surgeries performed in just two decadesAs many as half of these surgeries will lead to posterior capsular opacificationPCOwhich requires follow up Nd YAG laser capsulotomy surgeryWithout this additional procedurepatients can suffer permanent vision loss and disabilityIn many countri ...

PROJECT SUMMARY Men who have sex with menMSMaccount for nearly two thirds all of new HIV infections in the United StatesUSand young MSMYMSMare the only risk group experiencing a significant increase in HIV incidenceAmong youthpercent report not disclosing to their first time sex partnersDisclosing of one s HIV status is important for accessing support which can lead to improved medication adherenc ...

Our goal is to develop a firstin class therapeutic agent that directly blocks the metabolism of fructosea key component in sugarIntake of sugarsucroseand high fructose corn syrupHFCSinduces metabolic syndrome and diabetes in laboratory animals and are strongly associated with obesity and diabetes in humansBoth sucrose and HFCS contain fructosewhich stimulates food intake by inducing leptin resista ...

Project SummaryMyocardial infarctionMIoccurs inAmericans annually accounting for a mortality ofWhile percutaneous coronary interventionPCIis invariably successful in restoring epicardial patencysignificant microvascular obstructionMVOresulting in theno reflow phenomenonNRFoccurs frequently which significantly impacts mortality and the development of CHFCurrent devices are only partially effective ...

DESCRIPTION (provided by applicant): Anemia is a frequent finding in patients with chronic kidney disease (CKD) and is present in over 90% of CKD patients with end-stage renal disease. Anemia typically results from inability of the diseased kidney to produce erythropoietin (EPO), which stimulates production of red blood cells. Anemia leads to fatigue, a decreased quality of life and correlates wit ...

Abstract As the most important inhibitory neurotransmitter in the braina detailed understanding of the implications of gamma aminobutyric acidGABArelease remains elusiveThe measurement of GABA concentrations is a difficult processMicrodialysis is the current standard for GABA sampling in the brains of freely moving animalsbut suffers from low temporal resolution and the need for labor intensive an ...

DESCRIPTION (provided by applicant): The objective of the proposed SBIR Phase-II Competing Renewal under RFA-EY-09-001 is to develop inexpensive and compact ophthalmic instruments for rapid diabetic retinopathy (DR) detection and screening. To achieve the program objective, the key aims will be to [1] generate functional swept-source optical coherence tomography (F-SS-OCT) system at 1060nm spectra ...

DESCRIPTION (provided by applicant): Glycan (carbohydrate microarrays), carrying tens or hundreds of different sugars that are immobilized on solid surfaces in a spatially discrete pattern, possess a wide variety of potential applications in glycomics including rapid determination of the binding profile of carbohydrate-binding proteins, detection of specific antibodies for the diagnosis of disease ...