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CHEMEX PHARMACEUTICALS, INC.'S, NORDIHYDROGUAIARETIC ACID (CHX 100) IS A POTENT ANTIOXIDANT ALSO POSSESSING ANTIPROLIFERATIVE, ANTITUMOR, AND LIPOXYGENASE INHIBITION ACTIVITIES. THESE ACTIONS, ESPECIALLY ITS ANTIOXIDANT AND LIPOXYGENASE INHIBITORY ACTIVITIES, SUGGEST THAT CHX 100 MAY REDUCE THE DELETERIOUS EFFECTS OF ACUTE ULTRAVIOLET LIGHT (UVL) EXPOSURE ON THE SKIN, AS THESE EFFECTS MAY BE ASSOC ...

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THE LONG-TERM OBJECTIVE OF THIS PROJECT IS A BETTER UNDERSTANDING OF INFANT AND TODDLER MOTOR DEVELOPMENT. SPECIFIC AIMS INCLUDE THE DEVELOPMENT AND VALIDATION OF NEW STRATEGIES FOR ANALYZING MOTOR BEHAVIOR WITH EMPHASIS ON QUALITY OF MOVEMENT. QUALITY OF MOVEMENT WILL BE OPERATIONALIZED AS: (1) VARIATIONS WITHIN A POSITION, (2) TRANSITIONS WITHIN A POSITION, (3) COMPLEX COMBINATIONS OF SINGLE MOT ...

SINCE THE EARLY 20TH CENTURY, IT HAS BEEN RECOGNIZED THAT MEDICAL RADIOGRAPHICS ARE DEGRADED BY THE EFFECTS OF SCATTER. BEGINNING WITH THE INITIAL DEVELOPMENT OF THE BUCKY GRID AND CONTINUING THROUGH MANY IMPROVEMENTS AND ALTERNATIVES, ATTEMPTS TO CONTROL THE AMOUNT OF SCATTER WHILE MAXIMIZING THE TRANSMISSION OF UNSCATTERED PRIMARY RADIATION HAVE ACHIEVED ONLY MODERATE SUCCESS. IN CURRENT STATE-O ...

IT IS PROPOSED TO DEVELOP A LASER TO PERFORM NON-CONTACT TREPHINATION OF THE CORNEA. THIS LASER COULD GREATLY IMPROVE THE OUTCOME OF MORE THAN 30,000 CORNEAL TRANSPLANTATIONS PERFORMED YEARLY IN THE UNITED STATES. DURING PHASE I, THE AIMS OF THE RESEARCH ARE TO MODIFY AN EXISTING LABORATORY HF LASER FOR CORNEAL TREPHINATION, TO DEMONSTRATE REPRODUCIBLE, HIGH QUALITY CIRCULAR CORNEAL BUTTON, TO COM ...

THE LONG-TERM OBJECTIVES OF THIS PROJECT ARE TO DEVELOP METHODOLOGIES AND A KNOWLEDGE BASE THAT WILL ENHANCE THE UTILIZATION OF FELINE T-CELL LYMPHOTROPIC LENTIVIRUS (FTLV) AS A SMALL-LABORATORY ANIMAL MODEL OF HIV. IN PHASE I, A FTLV ANTIGEN TEST WILL BE DEVELOPED THAT WILL AUGMENT EXISTING ANTIBODY TESTS AND PROVIDE VETERINARIANS AND RESEARCH SCIENTISTS WITH DIAGNOSTIC TOOLS TO MONITOR FTLV INFE ...

THE NUMBER OF CASES OF HUMAN DIARRHEA ATTRIBUTED TO CRYPTOSPORIDIUM PARVUM HAS INCREASED DRAMATICALLY IN THE LAST DECADE. IN IMMUNOCOMPROMISED INDIVIDUALS, MOST NOTABLYAIDS PATIENTS, CRYPTOSPORIDIOSIS CAN PRESENT AS A FULMINANT AND PERSISTENT DIARRHEA. THERE IS CURRENTLY NO KNOWN CHEMOTHERAPEUTIC AGENT THAT IS EFFECTIVE AGAINST THIS COCCIDIAN PARASITE. AS A RESULT, THE MORTALITY RATE FOR CRYPTOSPO ...

THE ULTIMATE GOAL OF PROJECT TRANSITION IS TO BRING ABOUT INCREASED EARLY INTERVENTION IN AND PREVENTION OF ABUSIVE ALCOHOL USE PATTERNS AMONG DIVORCED AND SEPARATED WOMEN WHO ARE KNOWN TO BE AT RISK OF SUBSTANCE ABUSE BY DEVELOPING LOW-COST, NONSTIGMATIZED EDUCATIONAL MATERIALS THAT CAN BE DISTRIBUTED BY THE NATURAL NETWORK OF SERVICE PROVIDERS WHO REGULARLY COME INTO CONTACT WITH THIS POPULATION ...

DECREASING RESOURCES, HIGH WORKER TURNOVER RATES, AND AN INCREASING NUMBER OF CHILD MALTREATMENT REPORTS ARE TRENDS THAT ARE CHALLENGING SOCIAL SERVICE AGENCIES TO FIND INNOVATIVE WAYS TO DELIVER EFFECTIVE CHILD PROTECTIVE SERVICES (CPS) MORE EFFICIENTLY. THE PURPOSE OF THIS PROJECT IS TO DESIGN AND DEVELOP AN AUTOMATED JOB-AIDING SYSTEM, THE INVESTIGATION AND RISK ASSESSMENT SUPPORT SYSTEM (IRASS ...

A 22-KDA PROTEIN THAT HAS POTENT ACTIVITY AGAINST A NUMBER OF CLINICALLY IMPORTANT HUMAN PATHOGENS HAS BEEN ISOLATED FROM MAIZE SEEDS. IN ADDITION, THIS PROTEIN, NAMED ZEAMATIN, HAS THE UNIQUE ABILITY TO SYNERGIZE WITH KNOWN ANTIFUNGAL DRUGS, DECREASING THE DOSE REQUIRED FOR FUNGAL CELL KILLING WHILE INCREASING THE SPECTRUM OF ACTIVITY. AS A PRELUDE TO IN VIVO TESTING, IT IS PLANNED TO DETERMINE T ...