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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Polo box PLK Inhibitors Target Tumors Resistant to ATP Competitive Compounds

    SBC: PPI PHARMACEUTICALS, LLC            Topic: NCI

    Polo like kinase PLK is a central player in regulating entry into and progression through mitosis Many studies have validated PLK as an anti tumor drug target and its inhibition is potently anti proliferative to cancer cells However recent data suggests that there are two major disadvantages of the conventional approach to blocking the kinase activity of PLK First both general kinome ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Mindfulness Mobile App to Reduce Adolescent Substance Use

    SBC: OREGON RESEARCH BEHAVIORAL INTERVENTION STRATEGIES, INC.            Topic: NIDA

    ABSTRACT Adolescents in the juvenile justice system demonstrate very high rates of tobacco alcohol and other drug use ATOD with rates that are estimated to be three times higher than non justice involved youth Substance abusing youth especially those who are involved in the juvenile justice system are at higher risk than nonusers for mental health problems including depression conduct ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. SBIR grant application to develop and commercialize a urine based medical diagnostic for the detection of bladder cancer recurrence.

    SBC: Convergent Genomics, Inc.            Topic: NCI

    Bladder cancer is one of the most common forms of cancer in North AmericaMost oftenbladder cancer presents as superficial diseasewhich is treatable through surgical resectionbut is also associated with recurrence rates of up toThuspatients must be monitored at regular intervals following resection of the tumor to assess for recurrenceThis monitoring is done by cystoscopywhich requires a scope to b ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Nanoparticle based targeted codelivery of siRNA and taxane to treat drug resistant HER breast cancer

    SBC: PDX PHARMACEUTICALS, INC.            Topic: 102

    This SBIR Fast Track application focuses on the development of a nanoconstruct for co delivery of siRNA and chemotherapy drugs to drug resistant human epidermal growth factor receptor type positive HER breast cancer HER breast cancer is a subtype that presents HER overexpression and accounts for of invasive breast cancers HER breast cancer has poor prognosis despite the rigorou ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Fidelity, Assessment and Clinical Effectiveness Tracking (FACET) System: Making EBTs Feasible and Sustainable

    SBC: LIFFT, Co.            Topic: NIDA

    Advances in treating adolescent substance abuse and related problems have resulted in an increased emphasis on redirecting resources to transport evidence based treatmentsEBTsintoreal worldsettingsyet the science practice gap remains a pressing problemDue to highly complex and multifaceted processes involved in translating EBTs to practice settings and to a host of diffusion barriersincluding lack ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Prosody Assessment Toolbox

    SBC: BIOSPEECH INC            Topic: NIDCD

    Speech is generated by multiple organssuch as the lungsvocal chordsand the tongueall of which modulate sound over timeSome features of this modulation pattern convey identities of phonetic segmentswhat is saidComplementarysuprasegmentalfeatures refer to how it is saidThese features can have communicative functionsin which case we use the term prosodyThese communicative functions range from linguis ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Therapeutic Protein C Activator for Myocardial Ischemia

    SBC: ARONORA INC            Topic: NHLBI

    PROJECT SUMMARY Heart attackor acute myocardial infarctionAMIis a leading cause of death in the United Stateswith overvictims every yearThe most prevalent cause of AMI is progressive thrombotic coronary artery occlusionalso known as ST segment elevation myocardial infarctionSTEMIEarly therapy to promote heart reperfusion can dramatically improve outcomesWhile percutaneous coronary interventionPCIi ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Development of Deep Learning Models for Biomarker Identification and Classification

    SBC: AMPLION INC.            Topic: 400

    Nearly half of all biomedical publications ever written have been published in the last years the era since the completion of the human genome project The rate of increase is exponential shows no signs of slowing down and can be seen in all of the information sources relevant to precision medicine development This constitutes a nearly insurmountable burden for the drug development and diag ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. A Novel Scaffold to Promote Skin Regeneration

    SBC: FirstString Research, Inc            Topic: NIAMS

    PROJECT SUMMARY Dermal scarring affects more than million people worldwide annually over million people are injured in motor vehicle accidents over million patients are severely burned and thousands of warriors are wounded in military blasts In severe burns more than of patients develop hypertrophic scar contraction which leads to hypertrophic scar contractures HSc HSc a ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Turnkey THz Spectroscopy Polarimetry System for Pharmaceutical Applications

    SBC: Microtech Instruments, Inc.            Topic: 400

    ABSTRACT SUMMARY The outcome of this phase project will yield a turnkey system for spectroscopy polarimetry in the terahertz THz frequency range designed to support development of new drugs This system will directly probe protein vibrations using polarized terahertz radiation allowing researchers to rapidly characterize intramolecular vibrations which will help identify sites on ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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