Award Data

DESCRIPTION (provided by applicant): Highly potent, orally active, metabolically stable, long-lived opioid agents for the treatment of alcoholism that have decreased side effects such as nausea, addiction liability, immunosuppression and respiratory depression represents a great unmet need. While a mu opioid receptor antagonist is currently approved by the FDA for alcoholism, it possesses several ...

The overall goal of this research work is to design, build and evaluate high performance above-knee prosthetic systems suitable for military specific maneuvers. Existing above-knee prostheses are limited by the lack of compact energy sources, actuators, power regeneration methods, and control methods for active knee actuation. This proposal seeks to improve the dynamic performance of above-the-k ...

DESCRIPTION (provided by applicant): Psoriasis is a common, inflammatory disease of the skin characterized by hyperproliferation of keratinocytes. A variety of antipsoriatic therapies are available, however, due to problems with side effects and variability in clinical response, intense clinical and commercial interest remains in the development of new treatments. In the current studies, we are in ...

We propose to develop a computer based system for the online analysis of bio-behavioral signals associated with momentary loss of alertness. We will continue our development of bio-behavioral measures indicative of lapses in alertness. Our system will use only measures that can be obtained without attaching sensors to the operator. We will concentrate on monitoring the oculomotor system using came ...

DESCRIPTION (provided by applicant): Broad long term objectives and specific aims: The long-term objective of this project is to develop a digital anatomical research resource library of very high-resolution computational models, and imaging data sets. Our objective is to produce an anatomical library otf the complete human skeleton. The implications of this project, both scientific and social are ...

During the NAVY STTR Phase II Calnetix will further develop its concept of advanced flywheel system proposed in Phase I and will demonstrate the validity of the underlying principles through building and testing a system prototype. This prototype will be a fully functional system capable of supporting up to 2MW of pulse power with the ability of producing 500kW (30 seconds) loads in high-duty-cyc ...

In Phase II of this project we will capitalize on the successful incorporation of carbon nanotubes into carbon fabrics, by optimizing the process and scaling the technique for the manufacture of large 3-D composites that will be of use to the aerospace industry and the Air Force. In Phase I we successfully demonstrated the feasibility of incorporation of carbon nanotubes (CNTs) into carbon fibers ...

The objective of the proposed research is to use chemistry to modify single-walled carbon nanotubes (SWNTs) and engineer the interfacial interaction with polymers to synthesize composite materials with enhanced mechanical, electrical and thermal properties. We will conduct research on the synthesis and properties characterization of SWNT-reinforced composites based on epoxies and vinyl esters. Our ...

DESCRIPTION (provided by applicant): The goal of the proposed research is to scale up the production and manufacture of high-value ribonucleoside triphosphates containing stable isotope labels. The use for these products is in biomolecular studies of RNA structure using Nuclear Magnetic Resonance (NMR) spectroscopy. The market for these products is structural biology groups in academic and industr ...

DESCRIPTION (provided by applicant): Cepheid Inc and the New Jersey Medical School have developed an assay system that integrates sample processing and real-time PCR diagnosis into a single, hands free process. During the successful completion of a phase I STTR application we demonstrated that this system simultaneously detect the presence of Mycobacterium tuberculosis (TB) and diagnose rifampin r ...