Award Data

DESCRIPTION (provided by applicant): In the United States alone, 76,000 lives are claimed by liver disease every year. Transplantation is currently the only established treatment, but there is a critical shortage of donor organs. More than 60% of candidates wait over a year to receive a transplant, the majority becoming too ill to tolerate the procedure. These numbers could be improved dramatical ...

DESCRIPTION (provided by applicant): Type 2 diabetes is a particularly debilitating disease and is endemic for a large proportion of the world's population. The unmet challenges in disease management are the lack of long-term efficacy in reducing hyperglycemia and the inability to stop progression. Glucagon-like peptide-1 (GLP-1), a natural gut hormone, provides a platform for therapeutics to ...

DESCRIPTION (provided by applicant): The market for peptide and protein products is 30 billion annually and continues to grow. Automated solid phase peptide synthesis (SPPS) is a mainstay of modern medicinal research, and has been used on micromole up tometric ton industrial scale. Peptide drugs such as Exenatide, a GLP-1 analogue and a life-saver to many type-2 diabetes patients, and Fuzeon for ...

ABSTRACT: Triton Systems proposes to develop a novel computational model for complex particulate composite mixing processes and the resultant microstructures in high shear environments. Control of mixing of granular and particulate composites (e.g., particles in a polymer matrix) to achieve homogeneous mixtures is essential in many important functional material systems and applications, including ...

ABSTRACT: Aurora will demonstrate on our automated fiber placement (AFP) machine that we are able to lay up composite panels that contain sacrificial fibers that can be thermally decomposed to create a microvascular network of small cavities that allow the panel to act as a heat exchanger. The AFP machine is capable of producing composite parts from mold tools as large as 9"high by 18"wide by 56 ...

ABSTRACT: Information is a national asset that must be protected. To make effective use of this asset, information sharing is critical between government agencies, with foreign government partners, and with the private sector. At the same time, in practice, balancing information sharing and information protection can be difficult. Tools are needed to address many challenges, including managing ...

Physical Sciences Inc. and Colorado State University will develop an innovative sensor that enables low-cost infrared hyperspectral imaging though the use of novel sampling algorithms which provide real-world chemical plume detection capability with compressed data and a hardware configuration which enables high frame rate capture of full 2D spatial and 1D spectral data. Compressive sensing techn ...

SI2 Technologies, Inc. (SI2) proposes to develop printed, high-performance ultracapacitors to meet the Army"s need for lightweight energy storage. SI2 will leverage its demonstrated expertise in ink jet printing and our partner"s expertise with carbon nanoparticle synthesis to develop low-cost, flexible, printed ultracapacitors. SI2 has considerable experience in the roll-to-roll deposition of ...

ABSTRACT: Intelligence analysts need to process large amounts of text information to form an understanding of a topic of interest. The sheer amount of information can be overwhelming, so automated text analytics that assist with filtering, information extraction, and document understanding, can be highly beneficial. Deep natural language processing (NLP) applications require both structural knowl ...

ABSTRACT: High power and low insertion loss WDM components will be developed. In manufacturing WDM components, solid core fibers in both polarization insensitive and polarization maintaining, will be pursued, along with photonics crystal fiber components. A range of fiber sizes and device specifications will be developed and commercially offered by Q-Peak. The component that we propose to develo ...