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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Alpha-1 Antitrypsin Gene Therapy for Cystic Fibrosis

    SBC: Generx+, Inc.            Topic: N/A

    DESCRIPTION (Applicant's Abstract): The investigators have developed a plasmid vector that expresses the normal human alpha-1 antitrypsin (AAT) gene in human respiratory epithelium when delivered as a plasmid-cationic liposome complex. In subjects with inherited AAT deficiency, they showed that liposome mediated transfer of the normal AAT gene to the nasal respiratory epi ...

    STTR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  2. Ambulatory Detection of Asymptomatic Atrial Fibrillation

    SBC: Northwest Research Associates, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Project Summary/Abstract Atrial fibrillation is the most common disorder of the heart rhythm that requires treatment, with a prevalence estimated at over 5 million in the US alone in the year 2000. If untreated, it is a ssociated with increased risk of death and disability, primarily due to stroke. There is increasing evidence that a significant percentage of a ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  3. An Advanced Biosensor for Molecular Interaction Studies

    SBC: MOLECULAR SENSING, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Molecular interactions are central to the understanding of basic biology and cellular function, are paramount to all molecular assays (research and in vitro diagnostics), are essential in biomarker discovery and critical toward evaluating therapeutics. However, the tools available to quantify these interactions have limitations, in so far as they either rely up ...

    STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  4. An Advanced Biosensor for Molecular Interaction Studies.

    SBC: MOLECULAR SENSING, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Molecular interactions form the foundation of biology and chemistry. They are central to life itself and determine catalytic activity, cellular function, and therapeutic efficacy. The vast majority of diagnostic procedures depend on some type of specific molecular interaction. Therefore, the ability to perform pure liquid-phase molecular binding analysis at hi ...

    STTR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  5. A New Method For Discrimination of Tachycardia Sites

    SBC: Northwest Research Associates, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The standard interpretation of electocardiographic data does not allow differentiation of certain types of rhythm disorders, necessitating invasive testing. We believe that there is additional information contained in the ECG, in the form of small but systematic phase and amplitude changes that may provide important localization information. We will use inve ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  6. An Exotendon Prosthesis to Improve Walking for Lower Limb Amputees

    SBC: EMPOWERING ENGINEERING TECHNOLOGIES CORP            Topic: NIMHD

    DESCRIPTION (provided by applicant): The physical fitness and strength requirements for lower limb amputee gait are so high that thirty-seven percent of amputees are unable to walk with a prosthesis and another twenty-three percent are able to ambulate indoors only. Recent advances in prosthetic feet and knees have been unable to reduce these requirements, and external assistive devices like powe ...

    STTR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  7. An Expanded Genetic Information System

    SBC: ERAGEN BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (Applicant's abstract): The DNA alphabet is not limited to the four standard nucleotides. Rather, twelve nucleobases forming six base pairs joined by mutually exclusive hydrogen bonding patterns are possible within the geometry of the Watson-Crick base pair. These form An Expanded Genetic Information System (AEGIS), a new, "rule based" molecular re ...

    STTR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  8. AN EXPANDED GENETIC INFORMATION SYSTEM

    SBC: ERAGEN BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The DNA alphabet is not limited to the four standard nucleotides. Rather, twelve nucleobases forming six base pairs joined by mutually exclusive hydrogen bonding patterns are possible within the geometry of the Watson-Crick base pair. These form An Expanded Genetic Information System (Aegis), a new, "rule based" molecular recognition system that carries protein ...

    STTR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  9. AN EXPANDED GENETIC INFORMATION SYSTEM

    SBC: ERAGEN BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The DNA alphabet is not limited to the four standard nucleotides. Rather, twelve nucleobases forming six base pairs joined by mutually exclusive hydrogen bonding patterns are possible within the geometry of the Watson-Crick base pair. These form An Expanded Genetic Information System (Aegis), a new, "rule based" molecular recognition system that carries protein ...

    STTR Phase II 2002 Department of Health and Human ServicesNational Institutes of Health
  10. An Immersive Virtual Reality Peer Support Application for Individuals with Opioid Use Disorder: Development and Initial Evaluation

    SBC: Very Real Help, LLC            Topic: NIDA

    PROJECT SUMMARY Drug overdoses are the leading cause of death in the United States with approximately 72,000 people dying from drug overdose in 2017. Many of these fatalities occurred in individuals with opioid use disorder (OUD), which is one of the greatest public health issues confronting the United States today. Digital Recovery Support Services (DRSs) that include peer support, psychoeducatio ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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