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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. I-RED Southeast XLerator Network: Business Fundamentals for Core Facility Directors

    SBC: XLERATEHEALTH, LLC            Topic: NIGMS

    Project Summary Biomedical research is increasingly reliant on sophisticated technology that requires advanced technical skills. This shift in structure of academic research environments demands sufficient resources to perpetuate cutting edge research programs. Therefore, there is an increasing need for highly functional institutionally-based cores providing services with a rate structure that fac ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Using siRNAs against tau circular RNAs as a rational therapy for Alzheimer's disease

    SBC: CircCure Corporation            Topic: R

    Summary:The formation of neurofibrillary tangles (NFT) formed by aggregation of the microtubule-associated protein tau (MAPT) is a hallmark of Alzheimer’s disease (AD) and the likely cause of neuronal death. Currently, there are no rational treatments available that directly target NFT formation and thus address the direct molecular cause for AD. Based on our academic research, we will develop a ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  3. Label-free, Multimodality Diffuse Reflectance and Polarization-Based Proximity Probe for Iatrogenic Nerve Injury Prevention During Surgical Procedures

    SBC: YAYA SCIENTIFIC LLC            Topic: NIBIB

    PROJECT SUMMARY We propose to develop a novel contact, label-free multimodality-based sensing probe that provides real-time intraoperative identification of nerves within the thermal damage threshold range of a surgical tool. The tool will facilitate prevention of direct/indirect nerve damage (termed iatrogenic nerve injury) during surgical procedures, as they are a major source of postsurgical co ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. Engineered Exosomes for Targeted Delivery of the CRISPR/Cas9 Genome-editor

    SBC: 3P BIOTECHNOLOGIES, INC.            Topic: OD

    Technical AbstractGenetic mutations have been identified as a causative factor in numerous diseases. The genome editing system CRISPR/Cas9 is a recent development in gene therapy. Both viral and non-viral vectors have been used in attempts to direct delivery of Cas9 to specific locations with advantages and limitations similar to those known for other nucleic acid-based therapeutics. These challen ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Real-Time Quantitation of Transport Across Vascular-Tissue Interfaces in Organ-On-Chip Models Using In Situ Mass Spectrometry

    SBC: CFD RESEARCH CORPORATION            Topic: 400

    Abstract Current in vitro platforms are poor predictors of the in vivo safety, efficacy and pharmacokinetics of therapeutics, owing to a significant difference in the test conditions compared to physiological conditions. Therefore, drug toxicity testing is routinely performed using animal models. However, animal testing is expensive and time consuming. In addition, ethical concerns about the use o ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Portable Affordable Innovative and Smart Device-Coupled Electronic Fetal Monitoring System to Improve Rural Access to Obstetrics Services and Improve Outcomes in Rural Communities

    SBC: Fetal Life, LLC            Topic: 102

    PROJECT SUMMARY To ensure fetal well-being, obstetricians monitor fetal heartrate (FHR) and uterine contractions on a weekly to bi-weekly basis towards the end of pregnancy and during labor. Such monitoring is performed with an electronic fetal monitor (EFM) to decrease the development of complications while minimizing the need for unnecessary obstetric interventions. This is especially important ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Cell permeant peptidomimetics to prevent delayed vasospasm and neurological deficits after subarachnoid hemorrhage

    SBC: VasaMetrix            Topic: 107

    PROJECT SUMMARYSubarachnoid hemorrhage (SAH) due to rupture of an intracranial aneurysm leads to delayed vasospasm resulting in neuroischemia (stroke). The overall morbidity (profound neurologic deficit in 10-20% of survivors) and mortality (50%) are high, and the disease affects a relatively young adult population. Therapeutic options to prevent delayed vasospasm and neuroischemia after SAH are c ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Pulmonary Surface Irregularity score: A Quantitative CT Biomarker for Idiopathic Pulmonary Fibrosis

    SBC: AI METRICS, LLC            Topic: NIGMS

    PROJECT SUMMARY:Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic lung disease, with 50,000 new cases per year in the United States. IPF if a rapidly progressive and fatal disease, with half of patients dying within 2 years. The disease is heterogeneous, and there is wide variability in responsiveness to existing antifibrotic therapies. Development of new therapeutic agents for IPF a ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Universal affinity membrane chromatography for rapid, one-step purification of proteins

    SBC: TriAltus Bioscience, LLC            Topic: 400

    Project Summary The goal of this STTR Phase I project is to demonstrate the feasibility of developing the first universal affinity membrane for the rapid, selective, one-step purification of difficult-to-purify proteins. Despite the urgency for expanding the application of gene editing systems and accelerating vaccine and antibody test development, the rapid purification of critical proteins such ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. Selective Androgen Receptor Degraders (SARDs) as new therapeutics for spinal and bulbar muscular atrophy (SBMA)

    SBC: ONCTERNAL THERAPEUTICS, INC.            Topic: NINDS

    PROJECT SUMMARY Kennedy’s disease also known as spinobulbar muscular atrophy (SBMA) is a progressive neurodegenerative disease caused by genetic polyglutamine expansion of the androgen receptor (AR). Recent research has shown that the mutant AR protein misfolds, aggregates, and abnormally interacts with other proteins, leading to hormone-dependent lower motor neuron degeneration and skeletal mus ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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