Award Data

For effective protection against EMP and HPM threats, it is important to understand the physics of the threats, and also to quantify the effects they have on electrical systems. EMP and HPM vulnerability testing requires delivery of high peak power and electric fields to distant targets. The most practical solution to simulate such environments is to develop a modular, optically-isolated MV-antenn ...

Mitigation of threats posed by transportation and storage of hazardous chemicals or defeat of targets containing biological and chemical agents requires basic investigations to characterize aerosol formation and dispersion. Advanced laser-based instrumentation are proposed that will be used to characterize the aerosol and gas phase dispersion of chemicals during an accidental or explosive release. ...

In this proposal, we aim to validate the human gut microbiome and arid soil as a source of antibiotic natural products (NPs ) by using ametagenomic NP discovery platform developed at Radiant Genomics. Recent studies suggest that the genomes of uncultivated microorganisms,like their cultivated counterparts, encode an enormous number of NPs. Gaining systematic access to NPs using standard, cultivati ...

Environmental DNA from three extreme samples will be isolated, cloned into a fosmid library (5760 clones) for sequencing. The sequencing datawill cover ~ 240 Megabases and will be assembled into contigs long enough (~ 40 Kilobases) to represent potential biosynthetic gene clusters(BGCs). This data will be compared to BGC databases looking for homology to antibiotic targets of DoD interest and with ...

The fundamental problem addressed by this SBIR proposal is the capability to uncover new entity types, relations and topics that are implicit in text documents.Joint inference offers an opportunity to make discoveries that are more accurate and more nuanced than traditional pipelined approaches, but the hypothesis space is more complex and extraordinarily large.In this project we propose to develo ...

Metronome Software develops a Domain Encryption (DomCrypt) system for securing Android-based Commercial Off The Shield (COTS) mobile devices. DomCrypt software suite, through its creation of separate DomCrypt-encrypted domains, provides the warfighters the means for accessing and dynamically sharing data in a variety of formats using COTS mobile devices. Metronome also employs a strong-security fo ...

Typical procedures for respirator masks sizing and protective fit test are time-consuming and user intensive, requiring taking anthropometric measurements of the wearer, sampling the wearers breathing zone and the use of specialized tools and equipment. The proposed software app aims to quickly, accurately and automatically perform respirator mask sizing and predict protective fit using only 2D im ...

Alphavirus infection, which may cause encephalitis and death, are recognized as potential biological warfare agents. There are no approved medical countermeasures against diseases caused by Alphaviruses. In this project, thermostable single domain antibodies capable of crossing the blood brain barrier (BBB) and neutralizing encephalitic viruses will be developed using Abzymes proprietary in vivo S ...

The final product will include a suite of three app-based puzzle games aligned to national math standards for number sense, algebraic thinking, and problem solving. The games will be designed for use in grade 5 and 6 classrooms where students develop and apply content expertise to solving challenges. The games will include an adaptive engine that assesses and adjusts content based on student level ...

In prior research and development, the team and their partners developed EdSurge Concierge, an online platform to facilitate school improvement. With this Phase I funding, the project team will develop and test a next prototype of the platform with improved capability to generate information administrators need to make decisions on selecting technology tools to drive school improvement. The protot ...