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The Award database is continually updated throughout the year. As a result, data for FY22 is not expected to be complete until September, 2023.
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A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
Improving the therapeutic efficacy of a lead vaccine against plague using a novel adjuvant systemSBC: FasCure Therapeutics LLC Topic: NIAID
DESCRIPTION provided by applicant FasCure Therapeutics focuses on the development of adjuvant systems to generate prophylactic and therapeutic immune responses The major objective of this Phase STTR proposal is to reformulate a lead plague subunit vaccine with a novel adjuvant system to improve its protective efficacy Yersinia pestis is the causative agent of bubonic and pneumonic plague ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
A biochemical companion diagnostic platform to measure kinase inhibitor pharmacodynamics in leukemiaSBC: MICROFLUIDIC INNOVATIONS, LLC Topic: 102
DESCRIPTION provided by applicant Kinase inhibitors created a new paradigm in chemotherapy and are a major focus of new oncology drug development The Bcr Abl inhibitor imatinib was a breakthrough drug for chronic myelogenous leukemia with overwhelming early results however at least of patients are either intolerant resistant or experience recurrence within years and individual respo ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
Diagnosing aggressive prostate cancer by spectroscopic photoacoustic tomographySBC: Vibronix, Inc. Topic: 102
DESCRIPTION provided by applicant Prostate cancer PCa is the No killer among male cancer patients The ultimate test is based on transrectal ultrasound guided needle biopsy and histological examination of fixed prostate tissues This conventional diagnostic procedure is invasive missing cases of cancer due to small sampling volume Moreover it leads to an overtreatment of patients du ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
Discovery of Oligodendrocyte StimulatorsSBC: Medosome Biotec, LLC Topic: 101
DESCRIPTION provided by applicant Up to of low birth weight preterm infants manifest some form of periventricular white matter injury PWMI making it the most common form of brain injury affecting premature infants In the US infants per year are born at risk for PWMI and about children per year will develop PWMI World wide infants will be born each year at ri ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
Macromolecule Crystallization Screening Results AnalysisSBC: iXpressGenes, Inc. Topic: 100
DESCRIPTION provided by applicant Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite techno ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
Lowering the Cost of Imaging for Retinal Microvasculature in Diabetic PatientsSBC: AEON IMAGING LLC Topic: W
DESCRIPTION provided by applicant Recently we found extensive remodeling of the microvasculature of the retina occurring in some diabetic patients much earlier than expected This provides the potential for novel biomarkers However the equipment is too expensive for most clinics and small practices These early retinal microvascular changes cannot be seen with routine clinical examination o ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
A Novel, Microscale, Distributable Sensor Technology for Ionizing RadiationSBC: CFD RESEARCH CORP Topic: DTRA14B004
Terrorist use of radioactive nuclear materials via nuclear and/or radiological dispersion devices (dirty bombs) is a serious threat. Therefore, it is critical to detect the proliferation of nuclear material. Critical challenges facing this objective include: (a) high sensitivity detection of signature emissions (e.g., gamma rays) from common radioactive isotopes behind shielding, and (b) cost-effe ...STTR Phase I 2015 Department of DefenseDefense Threat Reduction Agency
Novel Silica-Based Organic Polymer for Ambient Ionization Mass SpectrometrySBC: Prosolia, Inc. Topic: NIGMS
DESCRIPTION provided by applicant Most samples of chemical interest are complex mixtures making the usual combination of chromatography with mass spectrometry MS a natural choice However the increased demand for chemical analysis by mass spectrometry in many areas of science makes it imperative to increase efficiency of analysis by minimizing sample workup and overall analysis time which ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
Development of a Novel Membrane Protein Solubilization/Stabilization ScreenSBC: SOLUBLE THERAPEUTICS, INC Topic: 100
DESCRIPTION provided by applicant The increasing output of new integral membrane protein IMP structures is partially due to the availability of an increasing number of chemical variables such as detergents detergent like molecules lipids and solubilizing stabilizing additives It is clear that specific combinations and concentrations of these different variables are often necessary to impr ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health