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The Award database is continually updated throughout the year. As a result, data for FY22 is not expected to be complete until September, 2023.
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A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
Development of CaSR nutrient therapy for childhood diarrheaSBC: Medosome Biotec, LLC Topic: NICHD
Project Abstract Acute infectious diarrhea is a worldwide problem especially among infants young children and immune compromised patients Sadly million children die each year not because of the infections causing diarrhea but due to the associated dehydration The pro absorptive Oral Rehydration Solution ORS is the only recommended oral therapy for children with acute diarrhea yet it ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SA FasL engineered human islets as a novel product for the treatment of type diabetesSBC: FasCure Therapeutics LLC Topic: NIDDK
PROJECT SUMMARY Type diabetes T D is a chronic autoimmune disorder that affects of population worldwide Exogenous insulin treatment is the standard of care for T D but often negatively affects the quality of life and is ineffective in preventing recurrent hyperglycemia episodes and chronic complications Recent studies show that human islet allografts can restore long term normoglycemia ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
Personalized dosing of dichloroacetate for the treatment of rare and common diseasesSBC: Medosome Biotec, LLC Topic: NICHD
Pyruvate dehydrogenase complexPDCdeficiencyPDCDis a rare disease of mitochondrial energy failure in which the life of expectancy of affected children is severely truncatedTreatment of PDCD remains a seriousunmetchallengeThere has never been a controlled trial of any intervention for PDCDthusthere is no proven therapy for affected patientsDichloroacetateDCArepresents the first targeted therapy for ...STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
TheraBracelet: The first and only wearable to instantly improve stroke hand functionSBC: TheraBracelet, Inc. Topic: NICHD
Project SummaryPost stroke hand impairment is highly prevalent and severely restricts functional ability and independenceIn facteveryseconds a new stroke occursand stroke is recognized as the leading cause of long term disabilityYetthere is no assistive device to help hand function at homeevery dayduring activities of daily livingExisting devices such as hand opening orthoses are expensivee gMyomo ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
Commercialization of a Novel Therapeutic for Alzheimer's DiseaseSBC: CoPlex Therapeutics, LLC Topic: NIA
ABSTRACT Traditional mon therapeutictarget driven approaches to drug development for Alzheimer s diseaseADare becoming increasingly expensive and in many cases disappointingly unsuccessfulBased on preliminary in vitro and in vivo studies we have identified a novel small moleculemethyldimethyloxodihydrobenzo cnaphthyridinecarboxylateBNCthat significantly decreases neuroinflammation and production o ...STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
A Novel Probiotic Platform to Treat Necrotizing EnterocolitisSBC: Monon Bioventures LLC Topic: 300
PROJECT SUMMARY Probiotics hold enormous potential for promoting human health and treating disease One major hurdle to many probiotic products is their lack of persistence in the gut Monon Bioventures MBV and their research partners at the Research Institute at Nationwide Childrenandapos s Hospital RINCH are developing a novel enhanced tunable technology called ProNextTM that allows for a ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
Lowering the Cost of Imaging for Retinal Microvasculature in Diabetic PatientsSBC: AEON IMAGING LLC Topic: W
DESCRIPTION provided by applicant Recently we found extensive remodeling of the microvasculature of the retina occurring in some diabetic patients much earlier than expected This provides the potential for novel biomarkers However the equipment is too expensive for most clinics and small practices These early retinal microvascular changes cannot be seen with routine clinical examination o ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
A Novel, Microscale, Distributable Sensor Technology for Ionizing RadiationSBC: CFD RESEARCH CORP Topic: DTRA14B004
Terrorist use of radioactive nuclear materials via nuclear and/or radiological dispersion devices (dirty bombs) is a serious threat. Therefore, it is critical to detect the proliferation of nuclear material. Critical challenges facing this objective include: (a) high sensitivity detection of signature emissions (e.g., gamma rays) from common radioactive isotopes behind shielding, and (b) cost-effe ...STTR Phase I 2015 Department of DefenseDefense Threat Reduction Agency
Novel Mixed-mode TCAD-Commercial PDK Integrated Flow for Radiation Hardening By DesignSBC: CFD RESEARCH CORP Topic: DTRA16A003
Cost-effective application of advanced commercial electronics technologies in DoD space systems requires early development of radiation-hardened-by-design (RHBD) techniques, and use of simulations is critical to the efficiency of this process. CFDRC has developed an integrated, mixed-mode simulation approach allowing their NanoTCAD device physics simulator to interface with commercial circuit simu ...STTR Phase I 2017 Department of DefenseDefense Threat Reduction Agency