Award Data

In this proposal, we aim to validate the human gut microbiome and arid soil as a source of antibiotic natural products (NPs ) by using ametagenomic NP discovery platform developed at Radiant Genomics. Recent studies suggest that the genomes of uncultivated microorganisms,like their cultivated counterparts, encode an enormous number of NPs. Gaining systematic access to NPs using standard, cultivati ...

Aflatoxins are a paradigm among fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk forthe development of hepatocellular carcinoma. Currently, there are no known countermeasures that can selectively mitigate aflatoxin toxicity andthe available options are only symptomatic treatments. To meet this challenge, we propose to harness the microbio ...

Typical procedures for respirator masks sizing and protective fit test are time-consuming and user intensive, requiring taking anthropometric measurements of the wearer, sampling the wearers breathing zone and the use of specialized tools and equipment. The proposed software app aims to quickly, accurately and automatically perform respirator mask sizing and predict protective fit using only 2D im ...

To address the Chemical and Biological Defense programs (CBDs) need for medical countermeasures against mycotoxin intoxication, PhysicalOptics Corporation (POC) proposes to develop a new Mycotoxin Neutralization Treatment (MyNT). This proposed solution is based on neutralizingmycotoxin from its deleterious effects by acting on multiple levels of mycotoxin metabolism through the novel combination o ...

As a foundational component of a Layered Sensing architecture, Toyon proposes to develop a Multi-Modal Fusion Module (M2FM) capable ofconfirming detections from Chemical, Biological and Radiological (CBR) sensing networks by fusing together information from other (non-CBR)sensors. The module will provide information to assist operators in confirming an initial CBR detection or rejecting it as a fa ...

The modern warfighter faces the constant threat of endemic infections, multi-drug resistant bacteria and Biological Warfare Agents. In order to provide accurate front-line treatment that will curtail the overuse of antibiotics, a rapid and robust molecula

Industrial Microbes is developing a green fermentation platform to replace carbon-emitting petrochemical production with newer methods that build chemicals out of methane and carbon dioxide.Chemical production is a major source of carbon pollution, responsible for 18% of direct industrialemissions. Our innovation is an engineered microbe that can consume carbon dioxide and methane and produce a ch ...

The final product will include a suite of three app-based puzzle games aligned to national math standards for number sense, algebraic thinking, and problem solving. The games will be designed for use in grade 5 and 6 classrooms where students develop and apply content expertise to solving challenges. The games will include an adaptive engine that assesses and adjusts content based on student level ...

San Diego Composites, Inc. (SDC) is developing the Reinforced Additively Manufactured Compression Assisted Molding (RAMCAM) pod to produce on-demand, corrosion resistant, aluminum and stainless steel equivalent parts in less than three days. RAMCAM combines the advantageous 2 day lead time of custom parts produced by 3D printing with the 1 day forging of structural parts via composite compression ...