Award Data

DESCRIPTION (provided by applicant): The general physical is the most important medical visit for the delivery of preventive services including cancer prevention and early detection. Unfortunately, using current office systems, physicians have difficulty d elivering the preventive services patients are eligible to receive. Advances in interactive information technology offer great potential for im ...

DESCRIPTION (provided by applicant): While routine point-of-care blood chemistry measurements can now be performed in clinical settings, quantitative high-sensitivity immunoassay measurements cannot. Thus, low-level serum markers for a variety of life-threatening conditions, such as sepsis, cannot be performed at the point of care. IA Inc.'s immunosensors possess the requisite speed and sensitivit ...

Perchlorate is a widely-used component of solid fuel, missile and rocket propellants, explosives and pyrotechnics. It has been shown to reduce iodide uptake into the thyroid gland. The EPA has found Perchlorate contamination in 18 states and believes contamination may exist in as many as 39 states. In early January 2005, the National Academy of sciences, in an EPA-sponsored study, recommended a ...

DESCRIPTION (provided by applicant): Tissue engineering and cell therapy are a new and exciting approach to the treatment of acute and chronic diseases. The potential success of this therapeutic approach lies in the growing appreciation that most disease processes are not due to the lack of a single protein but develop due to alterations in complex interactions of a variety of cell products. Cell ...

DESCRIPTION (provided by applicant): The broad objective of this proposed research is to determine the effect of sodium thiosulfate on kidney stone formation. The drug will initially be studied in a rat model of nephrolithiasis and if the drug is shown to reduce risk of new stone formation we will study the drug in patients with nephrolithiasis. The long term goal is to bring a new therapy for kid ...

DESCRIPTION (provided by applicant): Intensive behavioral interventions are needed to stem the obesity epidemic. Unfortunately, effective implementation of behavioral therapies is limited by the lack of an accurate system for measuring behavior and delivering immediate reinforcement. This SBIR Phase I proposal focuses on testing the feasibility of an innovative wireless platform for shaping key w ...

DESCRIPTION (provided by applicant): Attention deficit hyperactivity disorder (ADHD) is the most commonly diagnosed psychiatric disorder in children. Psychostimulant medication and behavioral therapy -- both alone and in combination -- are the primary evidence-based treatments for the functional deficits associated with ADHD. Intensive behavior therapy can reduce the need to use medication. Unfort ...

DESCRIPTION (provided by applicant): Although surgery and radiation are typically used in the treatment of malignant gliomas, the prognosis and 5-year survival rate for these patents is very poor. Gliomas are typically radioresistant and represent one of the most difficult tumors to treat by noninvasive methods. Gemcitabine is a potent radiosensitizer whose clinical utility is limited by its inher ...

DESCRIPTION (provided by applicant): Project Summary: The laboratory mouse is an essential experimental resource for modern biomedical research. Scientists currently use hundreds of varieties and strains of mice, and generate over 10 million individual animals each year. Tens of millions of dollars of NIH funding annually support mouse model research, with millions directly allocated to the mainte ...

DESCRIPTION (provided by applicant): The increasing costs of therapy and the demonstrated benefits of improved treatment efficacy with early detection are important incentives to develop tumor diagnostic agents of greater specificity and sensitivity. Paramagnetic gadolinium complexes are widely used as MRI (magnetic resonance imaging) contrast agents to improve sensitivity and/or specificity duri ...