Award Data

Abstract Adolescents in the juvenile justice system demonstrate very high rates of tobaccoalcoholand other drug useATODwith rates that are estimated to be three times higher than non justice involved youthSubstanceabusing youthespecially those who are involved in the juvenile justice systemare at higher risk than nonusers for mental health problemsincluding depressionconduct problemspersonality di ...

Congenital genetic abnormalities are a leading cause of childhood mortality and morbidityWhile routine newborn screeningNBShas dramatically improved health outcomesmany congenital disorders such as Duchenne muscular dystrophyDMDand other congenital muscular dystrophiesCMDare not currently detected by routine NBSPresymptomatic identification through NBS is critical to facilitate earlier initiation ...

An estimatedof babies born worldwideapproximatelymillion each yearcurrently do not receive any newborn screening careNewborn screeningNBSis an immensely successful testing program that identifies those at increased risk for commontreatable congenital disordersthe pre symptomatic identification of these disorders in newborns enables the rapid initiation of treatments and reduces or prevents serious ...

PROJECT SUMMARY Sickle Cell DiseaseSCDaffectsAmericans and more thanmillion people globallyprimarily in economically disadvantaged populationsIt is estimated that nearlyof children born with SCD in these areas die before the age of fivealthoughcould be saved through simplecost effective treatments if diagnosed early according to World Health OrganizationEarly diagnosis of SCD remains a challenge i ...

ABSTRACTThe proposed interventionCulturally Responsible Stress ReductionA Mobile Mindfulness Application to Support Health Promotion for African AmericansCRSRis designed to encourage the use of mindfulness to mitigate the disproportionate amount of stress related health disparities facing African AmericansCurrent mindfulness approaches have been unsuccessful in engaging this populationThis proposa ...

ABSTRACTMicroarrays are an important research toolgenomics and proteomicsand clinical toolbiomarker discovery and diagnosisCurrent microarray processing methods are limited by slow assay kineticsare not amenable to automationand require high volume of expensive reagents buffersMiniaturization of these technologies has been explored to improve throughputThe demand for microarrays continues to grow ...

ABSTRACT Multiplex Platform for Point of Care Newborn Screening of HyperbilirubinemiaSBIR Phase IIBHyperbilirubinemiajaundiceaffects more than half of all newborns and is typically benign if identified and treated promptlyWithout proper treatmenthigh bilirubin leads to serious neurological dysfunction including neuro motorauditoryspeechcognitionand language disturbancesRapid identification of newb ...

PROJECT SUMMARYChromatin function is regulated by reversible histone post translational modificationsPTMsincluding lysine methylationacetylationand monoubiquitinationEvidence places histone monoubiquitinationubupstream of other chromatin PTMsacting as a critical signaling center that regulates cascades of downstream epigenetic enzymese ghistone methyltransferase enzymes or HMTsto modify gene trans ...

Project Summary The elderly population is rapidly increasing worldwide and those overyears old are expected to compriseof the total population byThese demographic changes will focus healthcare needs on those conditions more prevalent in the elderlyChronic woundssuch as venous leg ulcerspressure ulcers and diabetic ulcers are over represented in the elderly population and even now present a signifi ...

SUMMARY ABSTRACT Innearlysolid organ transplants were performed in the United Statesan increase ofover the past ten yearsOrgan transplantation requires lifelong immunosuppression to prevent rejection of the transplantMany new classes of drugs have been developed to combat the side effects and interactions common to immunosuppressantswith several agentssirolimuseverolimusand belataceptgaining momen ...